Cut-Offs and Response Criteria for the Hospital Universitario La Princesa Index (HUPI) and Their Comparison to Widely-Used Indices of Disease Activity in Rheumatoid Arthritis
Publication Date
September 07, 2016
Journal
PLOS ONE
Authors
Isidoro González Álvaro, Isabel Castrejón, Ana M. Ortiz, Esther Toledano, et al
Volume
11
Issue
9
Pages
e0161727
DOI
https://dx.plos.org/10.1371/journal.pone.0161727
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0161727
Scopus
84992340918
Mendeley
http://www.mendeley.com/research/cutoffs-response-criteria-hospital-universitario-la-princesa-index-hupi-comparison-widelyused-indice
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P.", "last_name"=>"Valdazo De Diego", "scopus_author_id"=>"6506875962"}, {"first_name"=>"M.", "last_name"=>"Valls", "scopus_author_id"=>"57191664968"}, {"first_name"=>"V.", "last_name"=>"Villaverde García", "scopus_author_id"=>"6506791766"}, {"first_name"=>"P.", "last_name"=>"Zarco Montejo", "scopus_author_id"=>"6506897333"}, {"first_name"=>"J.", "last_name"=>"Zubieta Tabernero", "scopus_author_id"=>"6507755563"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pmid"=>"27603313", "scopus"=>"2-s2.0-84992340918", "doi"=>"10.1371/journal.pone.0161727", "sgr"=>"84992340918", "pui"=>"612856785"}, "id"=>"82a533c2-6cc7-30cd-b2b8-7a4cb892d47c", "abstract"=>"OBJECTIVE To estimate cut-off points and to establish response criteria for the Hospital Universitario La Princesa Index (HUPI) in patients with chronic polyarthritis. METHODS Two cohorts, one of early arthritis (Princesa Early Arthritis Register Longitudinal [PEARL] study) and other of long-term rheumatoid arthritis (Estudio de la Morbilidad y Expresión Clínica de la Artritis Reumatoide [EMECAR]) including altogether 1200 patients were used to determine cut-off values for remission, and for low, moderate and high activity through receiver operating curve (ROC) analysis. The areas under ROC (AUC) were compared to those of validated indexes (SDAI, CDAI, DAS28). ROC analysis was also applied to establish minimal and relevant clinical improvement for HUPI. RESULTS The best cut-off points for HUPI are 2, 5 and 9, classifying RA activity as remission if ≤2, low disease activity if >2 and ≤5), moderate if >5 and <9 and high if ≥9. HUPI's AUC to discriminate between low-moderate activity was 0.909 and between moderate-high activity 0.887. DAS28's AUCs were 0.887 and 0.846, respectively; both indices had higher accuracy than SDAI (AUCs: 0.832 and 0.756) and CDAI (AUCs: 0.789 and 0.728). HUPI discriminates remission better than DAS28-ESR in early arthritis, but similarly to SDAI. The HUPI cut-off for minimal clinical improvement was established at 2 and for relevant clinical improvement at 4. Response criteria were established based on these cut-off values. CONCLUSIONS The cut-offs proposed for HUPI perform adequately in patients with either early or long term arthritis.", "link"=>"http://www.mendeley.com/research/cutoffs-response-criteria-hospital-universitario-la-princesa-index-hupi-comparison-widelyused-indice", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Other"=>3, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Other"=>3, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>6, "Arts and Humanities"=>1, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>4}, "Arts and Humanities"=>{"Arts and Humanities"=>1}}, "group_count"=>0}

Scopus | Further Information

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