Taxa of the Nasal Microbiome Are Associated with Influenza-Specific IgA Response to Live Attenuated Influenza Vaccine
Publication Date
September 19, 2016
Journal
PLOS ONE
Authors
Hannah M. Salk, Whitney L. Simon, Nathaniel D. Lambert, Richard B. Kennedy, et al
Volume
11
Issue
9
Pages
e0162803
DOI
https://dx.plos.org/10.1371/journal.pone.0162803
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162803
Web of Science
000383891900019
Scopus
84992389893
Mendeley
http://www.mendeley.com/research/taxa-nasal-microbiome-associated-influenzaspecificiga-response-live-attenuated-influenza-vaccine
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Mendeley | Further Information

{"title"=>"Taxa of the nasal microbiome are associated with influenza-specificIgA response to live attenuated influenza vaccine", "type"=>"journal", "authors"=>[{"first_name"=>"Hannah M.", "last_name"=>"Salk", "scopus_author_id"=>"55937265900"}, {"first_name"=>"Whitney L.", "last_name"=>"Simon", "scopus_author_id"=>"56433982800"}, {"first_name"=>"Nathanield", "last_name"=>"Lambert", "scopus_author_id"=>"55366480500"}, {"first_name"=>"Richard B.", "last_name"=>"Kennedy", "scopus_author_id"=>"7402555466"}, {"first_name"=>"Diane E.", "last_name"=>"Grill", "scopus_author_id"=>"7007088518"}, {"first_name"=>"Brian F.", "last_name"=>"Kabat", "scopus_author_id"=>"15764913400"}, {"first_name"=>"Gregory A.", "last_name"=>"Poland", "scopus_author_id"=>"7006264623"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84992389893", "sgr"=>"84992389893", "pui"=>"612821066", "isbn"=>"1932-6203", "pmid"=>"27643883", "doi"=>"10.1371/journal.pone.0162803"}, "id"=>"24a32244-12b9-3306-a63d-517f036c1ad3", "abstract"=>"? 2016 Salk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Live attenuated influenza vaccine (LAIV) has demonstrated varying levels of efficacy against seasonal influenza; however, LAIV may be used as a tool to measure interactions between the human microbiome and a live, replicating virus. To increase our knowledge of this interaction,we measured changes to the nasal microbiome in subjects who received LAIV to determine if associations between influenza-specific IgA production and the nasal microbiome exist after immunization with a live virus vaccine. The anterior nares of 47 healthy subjects were swabbed pre- (Day 0) and post- (Days 7 and 28) LAIV administration, and nasal washes were conducted on Days 0 and 28.We performed next-generation sequencing on amplified 16s rRNA genes and measuredmucosal influenza-specific IgA titers via enzyme-linked immunosorbent assay (ELISA). A significant increase in alpha diversity was identified (Observed,CHAO, and ACE) between Days 7 vs 0 (p-values = 0.017, 0.005, 0.005, respectively) and between Days 28 vs 0 (p-values = 0.054, 0.030, 0.050, respectively). Several significant associations between the presence of different microbial species, including Lactobacillus helveticus, Prevotella melaninogenica, Streptococcus infantis, Veillonella dispar, and Bacteroides ovatus, and influenza-specific H1 and H3 IgA antibody response were demonstrated. These data suggest that LAIV alters the nasal microbiome, allowing several less-Abundant OTUs to establish a community niche. Additionally, specific alterations in the nasal microbiome are significantly associated with variations in influenza-specific IgA antibody production and could be clinically relevant.", "link"=>"http://www.mendeley.com/research/taxa-nasal-microbiome-associated-influenzaspecificiga-response-live-attenuated-influenza-vaccine", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>1, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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