An n=1 Clinical Network Analysis of Symptoms and Treatment in Psychosis
Publication Date
September 19, 2016
Journal
PLOS ONE
Authors
Maarten Bak, Marjan Drukker, Laila Hasmi & Jim Van Os
Volume
11
Issue
9
Pages
e0162811
DOI
https://dx.plos.org/10.1371/journal.pone.0162811
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162811
Web of Science
000383891900020
Scopus
84992350011
Mendeley
http://www.mendeley.com/research/n1-clinical-network-analysis-symptoms-treatment-psychosis
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Mendeley | Further Information

{"title"=>"An n=1 Clinical network analysis of symptoms and treatment in psychosis", "type"=>"journal", "authors"=>[{"first_name"=>"Maarten", "last_name"=>"Bak", "scopus_author_id"=>"7103144433"}, {"first_name"=>"Marjan", "last_name"=>"Drukker", "scopus_author_id"=>"6603281657"}, {"first_name"=>"Laila", "last_name"=>"Hasmi", "scopus_author_id"=>"57190390996"}, {"first_name"=>"O. S.", "last_name"=>"Van Jim", "scopus_author_id"=>"57191675986"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"612821064", "sgr"=>"84992350011", "issn"=>"19326203", "pmid"=>"27643994", "scopus"=>"2-s2.0-84992350011", "doi"=>"10.1371/journal.pone.0162811", "isbn"=>"1932-6203"}, "id"=>"f32ab73a-c208-303f-ba2e-16a07ad74dfd", "abstract"=>"Introduction Dynamic relationships between the symptoms of psychosis can be shown in individual net- works of psychopathology. In a single patient, data collected with the Experience Sampling Method (ESM–a method to construct intensive time series of experience and context) can be used to study lagged associations between symptoms in relation to illness severity and pharmacological treatment. Method The patient completed, over the course of 1 year, for 4 days per week, 10 daily assessments scheduled randomly between 10 minutes and 3 hours apart. Five a priori selected symp- toms were analysed: ‘hearing voices’, ‘down’, ‘relaxed’, ‘paranoia’ and ‘loss of control’. Regression analysis was performed including current level of one symptom as the depen- dent variable and all symptoms at the previous assessment (lag) as the independent vari- ables. Resulting regression coefficients were printed in graphs representing a network of symptoms. Network graphs were generated for different levels of severity: stable, impend- ing relapse and full relapse. Results ESM data showed that symptoms varied intensely from moment to moment. Network repre- sentations showed meaningful relations between symptoms, e.g. ‘down’ and ‘paranoia’ fuel- ling each other, and ‘paranoia’ negatively impacting ‘relaxed’. During relapse, symptom levels as well as the level of clustering between symptoms markedly increased, indicating qualitative changes in the network. While ‘hearing voices’ was the most prominent symptom subjectively, the data suggested that a strategic focus on ‘paranoia’, as the most central symptom, had the potential to bring about changes affecting the whole network. Conclusion Construction of intensive ESM time series in a single patient is feasible and informative, par- ticularly if represented as a network, showing both quantitative and qualitative changes as a function of relapse.", "link"=>"http://www.mendeley.com/research/n1-clinical-network-analysis-symptoms-treatment-psychosis", "reader_count"=>71, "reader_count_by_academic_status"=>{"Unspecified"=>6, "Professor > Associate Professor"=>4, "Researcher"=>9, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>6, "Professor > Associate Professor"=>4, "Researcher"=>9, "Student > Doctoral Student"=>8, "Student > Ph. D. Student"=>18, "Student > Postgraduate"=>5, "Student > Master"=>7, "Other"=>4, "Student > Bachelor"=>7, "Lecturer"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>7, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>3, "Psychology"=>49, "Social Sciences"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Neuroscience"=>{"Neuroscience"=>3}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>49}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>7}}, "group_count"=>4}

Scopus | Further Information

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