Prenatal Clinical Assessment of NT-proBNP as a Diagnostic Tool for Preeclampsia, Gestational Hypertension and Gestational Diabetes Mellitus
Publication Date
September 29, 2016
Journal
PLOS ONE
Authors
Pawel Sadlecki, Marek Grabiec & Malgorzata Walentowicz-Sadlecka
Volume
11
Issue
9
Pages
e0162957
DOI
https://dx.plos.org/10.1371/journal.pone.0162957
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0162957
Scopus
84991687519
Mendeley
http://www.mendeley.com/research/prenatal-clinical-assessment-ntprobnp-diagnostic-tool-preeclampsia-gestational-hypertension-gestatio
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Mendeley | Further Information

{"title"=>"Prenatal clinical assessment of NT-proBNP as a diagnostic tool for preeclampsia, gestational hypertension and gestational diabetes mellitus", "type"=>"journal", "authors"=>[{"first_name"=>"Pawel", "last_name"=>"Sadlecki", "scopus_author_id"=>"26645160900"}, {"first_name"=>"Marek", "last_name"=>"Grabiec", "scopus_author_id"=>"6602074878"}, {"first_name"=>"Malgorzata", "last_name"=>"Walentowicz-Sadlecka", "scopus_author_id"=>"35725010300"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84991687519", "doi"=>"10.1371/journal.pone.0162957", "scopus"=>"2-s2.0-84991687519", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "pmid"=>"27685993", "pui"=>"612795459"}, "id"=>"d023f4c4-7dc4-3454-9479-af122a96cdd0", "abstract"=>"Common complications of pregnancy include preeclampsia (PE), gestational hypertension (GH) and gestational diabetes mellitus (GDM). Hypertensive disorders (PE/GH) and GDM may result in greater maternal, fetal and neonatal morbidity and mortality. Women with PE/GH, one of the most common causes of heart burden in an obstetrical setting, present with elevated serum levels of BNP and NT-proBNP. The aim of this study was to shed more light on the role of NT-proBNP in pathophysiology of PE, GH and GDM. The study included 156 pregnant women with singleton pregnancies. A total of 26 women developed arterial hypertension during pregnancy, 14 were diagnosed with PE, and GDM was detected in 81 patients. The control group included 35 women with uncomplicated pregnancies, normal arterial blood pressure and normal glucose concentrations. Patients with GH presented with significantly higher serum concentrations of NT-proBNPthan normotensive women (65.5 vs. 37.4 pg/ml; p = 0.0136). Serum levels of NT-proBNP in patients with PE were the highest of all the analyzed subsets, being significantly higher than in women without this condition (89.00 vs. 37.4pg/ml,p = 0,0136). However, women with and without GDM did not differ significantly in terms of their serum NT-proBNPconcentrations. Serum NT-proBNP (pg/ml) (p = 0.0001) and BMI (p<0.0001) turned out to be independent predictors of GH on multivariate logistic regression analysis.Moreover, serum NT-proBNP (pg/ml) was identified as an independent indicator of PE (p = 0.0016). A significant inverse correlation was found between birth weight and maternal serum NT-proBNP concentrations. In our opinion, NT-proBNP can be a useful clinical marker of GH and PE. Determination of NT-proBNP levels may be helpful in identification of patients with PE and GH and in their qualification for intensive treatment; this in turn, may be reflected by better neonatal outcomes.", "link"=>"http://www.mendeley.com/research/prenatal-clinical-assessment-ntprobnp-diagnostic-tool-preeclampsia-gestational-hypertension-gestatio", "reader_count"=>23, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>1, "Student > Master"=>8, "Other"=>2, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>3, "Medicine and Dentistry"=>12, "Agricultural and Biological Sciences"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Social Sciences"=>2, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>12}, "Chemistry"=>{"Chemistry"=>1}, "Social Sciences"=>{"Social Sciences"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Computer Science"=>{"Computer Science"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>2}

Scopus | Further Information

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