Isoflurane and Sevoflurane Induce Severe Hepatic Insulin Resistance in a Canine Model
Publication Date
November 01, 2016
Authors
Stella P. Kim, Josiane L. Broussard & Cathryn M. Kolka
Volume
11
Issue
11
Pages
e0163275
DOI
https://dx.plos.org/10.1371/journal.pone.0163275
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163275
Scopus
84994300362
Mendeley
http://www.mendeley.com/research/isoflurane-sevoflurane-induce-severe-hepatic-insulin-resistance-canine-model
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Mendeley | Further Information

{"title"=>"Isoflurane and sevoflurane induce severe hepatic insulin resistance in a canine model", "type"=>"journal", "authors"=>[{"first_name"=>"Stella P.", "last_name"=>"Kim", "scopus_author_id"=>"8732759600"}, {"first_name"=>"Josiane L.", "last_name"=>"Broussard", "scopus_author_id"=>"12784549800"}, {"first_name"=>"Cathryn M.", "last_name"=>"Kolka", "scopus_author_id"=>"8885867500"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0163275", "scopus"=>"2-s2.0-84994300362", "pui"=>"612983239", "issn"=>"19326203", "pmid"=>"27802272", "sgr"=>"84994300362"}, "id"=>"196b37d3-ae00-3631-825b-b9987cc5a5a8", "abstract"=>"INTRODUCTION Anesthesia induces insulin resistance, which may contribute to elevated blood glucose and adverse post-operative outcomes in critically ill patients, and impair glycemic control in surgical patients with diabetes. However, little is known about the mechanisms by which anesthesia impairs insulin sensitivity. Here we investigate the effects of anesthesia on insulin sensitivity in metabolic tissues. METHODS Hyperinsulinemic-euglycemic clamps were performed in 32 lean (control diet; n = 16 conscious versus n = 16 anesthetized) and 24 fat-fed (6 weeks fat-feeding; n = 16 conscious versus n = 8 anesthetized) adult male mongrel dogs in conjunction with tracer methodology to differentiate hepatic versus peripheral insulin sensitivity. Propofol was administered as an intravenous bolus (3mg/kg) to initiate anesthesia, which was then maintained with inhaled sevoflurane or isoflurane (2-3%) for the duration of the procedure. RESULTS Anesthesia reduced peripheral insulin sensitivity by approximately 50% in both lean and fat-fed animals as compared to conscious animals, and insulin action at the liver was almost completely suppressed during anesthesia such that hepatic insulin sensitivity was decreased by 75.5% and; 116.2% in lean and fat-fed groups, respectively. CONCLUSION Inhaled anesthesia induces severe hepatic insulin resistance in a canine model. Countermeasures that preserve hepatic insulin sensitivity may represent a therapeutic target that could improve surgical outcomes in both diabetic and healthy patients.", "link"=>"http://www.mendeley.com/research/isoflurane-sevoflurane-induce-severe-hepatic-insulin-resistance-canine-model", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Librarian"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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