Long-Term Oxygen Therapy 24 vs 15 h/day and Mortality in Chronic Obstructive Pulmonary Disease
Publication Date
September 20, 2016
Journal
PLOS ONE
Authors
Zainab Ahmadi, Josefin Sundh, Anna Bornefalk Hermansson & Magnus Ekström
Volume
11
Issue
9
Pages
e0163293
DOI
https://dx.plos.org/10.1371/journal.pone.0163293
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163293
Web of Science
000383892100076
Scopus
84991619724
Mendeley
http://www.mendeley.com/research/longterm-oxygen-therapy-24-vs-15-hday-mortality-chronic-obstructive-pulmonary-disease-1
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Mendeley | Further Information

{"title"=>"Long-term oxygen therapy 24 vs 15 h/day and mortality in chronic obstructive pulmonary disease", "type"=>"journal", "authors"=>[{"first_name"=>"Zainab", "last_name"=>"Ahmadi", "scopus_author_id"=>"55382788800"}, {"first_name"=>"Josefin", "last_name"=>"Sundh", "scopus_author_id"=>"37027281700"}, {"first_name"=>"Anna", "last_name"=>"Bornefalk-Hermansson", "scopus_author_id"=>"56021580700"}, {"first_name"=>"Magnus", "last_name"=>"Ekström", "scopus_author_id"=>"35324433300"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84991619724", "pmid"=>"27649490", "doi"=>"10.1371/journal.pone.0163293", "pui"=>"612774175", "sgr"=>"84991619724"}, "id"=>"659e702c-e2d8-30c9-b770-5405372f1298", "abstract"=>"Long-term oxygen therapy (LTOT) ≥ 15 h/day improves survival in hypoxemic chronic obstructive pulmonary disease (COPD). LTOT 24 h/day is often recommended but may pose an unnecessary burden with no clear survival benefit compared with LTOT 15 h/day. The aim was to test the hypothesis that LTOT 24 h/day decreases all-cause, respiratory, and cardiovascular mortality compared to LTOT 15 h/day in hypoxemic COPD. This was a prospective, observational, population-based study of COPD patients starting LTOT between October 1, 2005 and June 30, 2009 in Sweden. Overall and cause-specific mortality was analyzed using Cox and Fine-Gray regression, controlling for age, sex, prescribed oxygen dose, PaO2 (air), PaCO2 (air), Forced Expiratory Volume in one second (FEV1), WHO performance status, body mass index, comorbidity, and oral glucocorticoids. A total of 2,249 included patients were included with a median follow-up of 1.1 years (interquartile range, 0.6-2.1). 1,129 (50%) patients died and no patient was lost to follow-up. Higher LTOT duration analyzed as a continuous variable was not associated with any change in mortality rate (hazard ratio [HR] 1.00; (95% confidence interval [CI], 0.98 to 1.02) per 1 h/day increase above 15 h/day. LTOT exactly 24 h/day was prescribed in 539 (24%) patients and LTOT 15-16 h/day in 1,231 (55%) patients. Mortality was similar between the groups for all-cause, respiratory and cardiovascular mortality. In hypoxemic COPD, LTOT 24 h/day was not associated with a survival benefit compared with treatment 15-16 h/day. A design for a registry-based randomized trial (R-RCT) is proposed.", "link"=>"http://www.mendeley.com/research/longterm-oxygen-therapy-24-vs-15-hday-mortality-chronic-obstructive-pulmonary-disease-1", "reader_count"=>12, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>2, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Lecturer"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>2, "Nursing and Health Professions"=>4, "Medicine and Dentistry"=>6}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>2}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>6}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>1}

Scopus | Further Information

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