Overexpression of Ribosomal RNA in the Development of Human Cervical Cancer Is Associated with rDNA Promoter Hypomethylation
Publication Date
October 03, 2016
Journal
PLOS ONE
Authors
Hong Zhou, Yapei Wang, Qiongying Lv, Juan Zhang, et al
Volume
11
Issue
10
Pages
e0163340
DOI
https://dx.plos.org/10.1371/journal.pone.0163340
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163340
Scopus
84991497708
Mendeley
http://www.mendeley.com/research/overexpression-ribosomal-rna-development-human-cervical-cancer-associated-rdna-promoter-hypomethylat
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Mendeley | Further Information

{"title"=>"Overexpression of ribosomal RNA in the development of human cervical cancer is associated with rDNA promoter hypomethylation", "type"=>"journal", "authors"=>[{"first_name"=>"Hong", "last_name"=>"Zhou", "scopus_author_id"=>"56693241200"}, {"first_name"=>"Yapei", "last_name"=>"Wang", "scopus_author_id"=>"56655194900"}, {"first_name"=>"Qiongying", "last_name"=>"Lv", "scopus_author_id"=>"56487061300"}, {"first_name"=>"Juan", "last_name"=>"Zhang", "scopus_author_id"=>"56954926900"}, {"first_name"=>"Qing", "last_name"=>"Wang", "scopus_author_id"=>"57030921300"}, {"first_name"=>"Fei", "last_name"=>"Gao", "scopus_author_id"=>"56654641200"}, {"first_name"=>"Haoli", "last_name"=>"Hou", "scopus_author_id"=>"56124737000"}, {"first_name"=>"Hao", "last_name"=>"Zhang", "scopus_author_id"=>"57031392400"}, {"first_name"=>"Wei", "last_name"=>"Zhang", "scopus_author_id"=>"56693493200"}, {"first_name"=>"Lijia", "last_name"=>"Li", "scopus_author_id"=>"22433624000"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27695092", "scopus"=>"2-s2.0-84991497708", "sgr"=>"84991497708", "doi"=>"10.1371/journal.pone.0163340", "pui"=>"612643903", "issn"=>"19326203"}, "id"=>"f1740479-2fa3-33a5-871f-080ec1639e3d", "abstract"=>"The ribosomal RNA (rRNA) gene encodes rRNA for protein synthesis. Aberrant expression of the rRNA gene has been generally observed in tumor cells and levels of its promoter methylation as an epigenetic regulator affect rRNA gene transcription. The possible relationship between expression and promoter methylation of rDNA has not been examined in human clinical cervical cancer. Here we investigate rRNA gene expression by quantitative real time PCR, and promoter methylation levels by HpaII/MspI digestion and sodium bisulfite sequencing in the development of human cervical cancer. We find that indeed rRNA levels are elevated in most of cervical intraepithelial neoplasia (CIN) specimens as compared with non-cancer tissues. The rDNA promoter region in cervical intraepithelial neoplasia (CIN) tissues reveals significant hypomethylation at cytosines in the context of CpG dinucleotides, accompanied with rDNA chromatin decondensation. Furthermore treatment of HeLa cells with the methylation inhibitor drug 5-aza-2'-deoxycytidine (DAC) demonstrates the negative correlation between the expression of 45S rDNA and the methylation level in the rDNA promoter region. These data suggest that a decrease in rDNA promoter methylation levels can result in an increase of rRNA synthesis in the development of human cervical cancer.", "link"=>"http://www.mendeley.com/research/overexpression-ribosomal-rna-development-human-cervical-cancer-associated-rdna-promoter-hypomethylat", "reader_count"=>13, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>4}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Student > Bachelor"=>4}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>6, "Agricultural and Biological Sciences"=>5, "Immunology and Microbiology"=>2}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>6}}, "group_count"=>0}

Scopus | Further Information

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