Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients
Publication Date
September 20, 2016
Journal
PLOS ONE
Authors
Marianoel Pereira Gómez, Juan Vicente Bou, Iván Andreu & Rafael Sanjuán
Volume
11
Issue
9
Pages
e0163363
DOI
https://dx.plos.org/10.1371/journal.pone.0163363
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163363
Scopus
84992413022
Mendeley
http://www.mendeley.com/research/lamivudineadefovir-treatment-increases-rate-spontaneous-mutation-hepatitis-b-virus-patients-1
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Mendeley | Further Information

{"title"=>"Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients", "type"=>"journal", "authors"=>[{"first_name"=>"Marianoel", "last_name"=>"Pereira-Gómez"}, {"first_name"=>"Juan-Vicente", "last_name"=>"Bou"}, {"first_name"=>"Iván", "last_name"=>"Andreu"}, {"first_name"=>"Rafael", "last_name"=>"Sanjuán"}], "year"=>2016, "source"=>"PLOS ONE", "identifiers"=>{"pmid"=>"27649318", "doi"=>"10.1371/journal.pone.0163363", "issn"=>"1932-6203"}, "id"=>"b70b0b95-9a64-344c-bcab-e3032d143fa6", "abstract"=>"The high levels of genetic diversity shown by hepatitis B virus (HBV) are commonly attributed to the low fidelity of its polymerase. However, the rate of spontaneous mutation of human HBV in vivo is currently unknown. Here, based on the evolutionary principle that the population frequency of lethal mutations equals the rate at which they are produced, we have estimated the mutation rate of HBV in vivo by scoring premature stop codons in 621 publicly available, full-length, molecular clone sequences derived from patients. This yielded an estimate of 8.7 × 10-5 spontaneous mutations per nucleotide per cell infection in untreated patients, which should be taken as an upper limit estimate because PCR errors and/or lack of effective lethality may inflate observed mutation frequencies. We found that, in patients undergoing lamivudine/adefovir treatment, the HBV mutation rate was elevated by more than sixfold, revealing a mutagenic effect of this treatment. Genome-wide analysis of single-nucleotide polymorphisms indicated that lamivudine/adefovir treatment increases the fraction of A/T-to-G/C base substitutions, consistent with recent work showing similar effects of lamivudine in cellular DNA. Based on these data, the rate at which HBV produces new genetic variants in treated patients is similar to or even higher than in RNA viruses.", "link"=>"http://www.mendeley.com/research/lamivudineadefovir-treatment-increases-rate-spontaneous-mutation-hepatitis-b-virus-patients-1", "reader_count"=>6, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>2, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Agricultural and Biological Sciences"=>2, "Physics and Astronomy"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"Colombia"=>1}, "group_count"=>0}

Scopus | Further Information

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