Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages
Publication Date
October 13, 2016
Journal
PLOS ONE
Authors
Aichurek Soultanova, Zbigniew Mikulski, Uwe Pfeil, Veronika Grau, et al
Volume
11
Issue
10
Pages
e0163483
DOI
https://dx.plos.org/10.1371/journal.pone.0163483
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163483
Scopus
84991660347
Mendeley
http://www.mendeley.com/research/calcitonin-peptide-family-members-differentially-regulated-lps-inhibit-functions-rat-alveolar-nr8383
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Mendeley | Further Information

{"title"=>"Calcitonin peptide family members are differentially regulated by LPS and inhibit functions of rat alveolar NR8383 macrophages", "type"=>"journal", "authors"=>[{"first_name"=>"Aichurek", "last_name"=>"Soultanova", "scopus_author_id"=>"56292171100"}, {"first_name"=>"Zbigniew", "last_name"=>"Mikulski", "scopus_author_id"=>"32867978700"}, {"first_name"=>"Uwe", "last_name"=>"Pfeil", "scopus_author_id"=>"6602708953"}, {"first_name"=>"Veronika", "last_name"=>"Grau", "scopus_author_id"=>"56266334100"}, {"first_name"=>"Wolfgang", "last_name"=>"Kummer", "scopus_author_id"=>"17035091600"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27737007", "doi"=>"10.1371/journal.pone.0163483", "pui"=>"612685836", "issn"=>"19326203", "sgr"=>"84991660347", "scopus"=>"2-s2.0-84991660347"}, "id"=>"39d87f24-3bb8-32f6-ada5-38c77aebfae3", "abstract"=>"Members of the calcitonin peptide family-calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and adrenomedullin2/intermedin (IMD)-exert modulatory effects upon monocytes and macrophages of various extrapulmonary origins. Utilizing the rat alveolar macrophage (AMphi) cell line NR8383, we here set out to determine to which extent these three peptides and their receptors are differentially regulated in AMphi and what specific effects they have on AMphi key functions. LPS treatment differentially up-regulated expression of the peptides and receptors. Among the three peptides, IMD mRNA content was lowest both in primary rat AMphi and NR8383 cells, whereas IMD peptide dominated in basal and LPS-stimulated secretion from NR8383 cells. Fcgamma receptor-mediated phagocytosis and TNF-alpha production were inhibited by AM, IMD, and CGRP, whereas pro-IL-1beta mRNA was slightly down-regulated exclusively by CGRP. Neither of these peptides affected IL-6 or IL-10 production. None increased intracellular calcium concentration, but AM significantly inhibited store-operated calcium entry. In conclusion, the rat AMphi cell line NR8383 is both a source and a target of the calcitonin peptide family members AM, IMD, and CGRP. Despite sharing proteins of the receptor complexes, AM, IMD, and CGRP each showed a characteristic pattern of effects and regulation, suggesting that these closely related peptides are not just redundant members of one common signaling pathway but act in concert by addressing parallel signaling cascades. Since peptide and receptor expression are up-regulated by LPS, these signaling pathways might act as inhibitory feedback mechanisms in pulmonary bacterial infection.", "link"=>"http://www.mendeley.com/research/calcitonin-peptide-family-members-differentially-regulated-lps-inhibit-functions-rat-alveolar-nr8383", "reader_count"=>5, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Agricultural and Biological Sciences"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>1}

Scopus | Further Information

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