NSG Mice Provide a Better Spontaneous Model of Breast Cancer Metastasis than Athymic (Nude) Mice
Publication Date
September 23, 2016
Journal
PLOS ONE
Authors
Madhavi Puchalapalli, Xianke Zeng, Liang Mu, Aubree Anderson, et al
Volume
11
Issue
9
Pages
e0163521
DOI
https://dx.plos.org/10.1371/journal.pone.0163521
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163521
Scopus
84992079902
Mendeley
http://www.mendeley.com/research/nsg-mice-provide-better-spontaneous-model-breast-cancer-metastasis-athymic-nude-mice
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Mendeley | Further Information

{"title"=>"NSG mice provide a better spontaneous model of breast cancer metastasis than athymic (nude) mice", "type"=>"journal", "authors"=>[{"first_name"=>"Madhavi", "last_name"=>"Puchalapalli", "scopus_author_id"=>"57191618549"}, {"first_name"=>"Xianke", "last_name"=>"Zeng", "scopus_author_id"=>"55461384000"}, {"first_name"=>"Liang", "last_name"=>"Mu", "scopus_author_id"=>"57191621981"}, {"first_name"=>"Aubree", "last_name"=>"Anderson", "scopus_author_id"=>"57191614073"}, {"first_name"=>"Laura Hix", "last_name"=>"Glickman", "scopus_author_id"=>"56602482100"}, {"first_name"=>"Ming", "last_name"=>"Zhang", "scopus_author_id"=>"7601555746"}, {"first_name"=>"Megan R.", "last_name"=>"Sayyad", "scopus_author_id"=>"57191618721"}, {"first_name"=>"Sierra Mosticone", "last_name"=>"Wangensteen", "scopus_author_id"=>"57191624381"}, {"first_name"=>"Charles V.", "last_name"=>"Clevenger", "scopus_author_id"=>"7006747165"}, {"first_name"=>"Jennifer E.", "last_name"=>"Koblinski", "scopus_author_id"=>"6507426489"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"612774873", "sgr"=>"84992079902", "issn"=>"19326203", "pmid"=>"27662655", "scopus"=>"2-s2.0-84992079902", "doi"=>"10.1371/journal.pone.0163521"}, "id"=>"a31709fc-62cc-3a66-85ea-7af3e0f2f5d0", "abstract"=>"Metastasis is the most common cause of mortality in breast cancer patients worldwide. To identify improved mouse models for breast cancer growth and spontaneous metastasis, we examined growth and metastasis of both estrogen receptor positive (T47D) and negative (MDA-MB-231, SUM1315, and CN34BrM) human breast cancer cells in nude and NSG mice. Both primary tumor growth and spontaneous metastases were increased in NSG mice compared to nude mice. In addition, a pattern of metastasis similar to that observed in human breast cancer patients (metastases to the lungs, liver, bones, brain, and lymph nodes) was found in NSG mice. Furthermore, there was an increase in the metastatic burden in NSG compared to nude mice that were injected with MDA-MB-231 breast cancer cells in an intracardiac experimental metastasis model. This data demonstrates that NSG mice provide a better model for studying human breast cancer metastasis compared to the current nude mouse model.", "link"=>"http://www.mendeley.com/research/nsg-mice-provide-better-spontaneous-model-breast-cancer-metastasis-athymic-nude-mice", "reader_count"=>30, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2, "Researcher"=>3, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>10, "Student > Postgraduate"=>2, "Student > Master"=>5, "Other"=>3, "Student > Bachelor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>12, "Materials Science"=>1, "Agricultural and Biological Sciences"=>8, "Medicine and Dentistry"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Chemistry"=>{"Chemistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>8}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>12}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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