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Quantitative Proteomic Profiling the Molecular Signatures of Annexin A5 in Lung Squamous Carcinoma Cells

Publication Date: September 29, 2016
Journal: PLOS ONE
Authors: Bing Sun, Yuxin Bai, Liyuan Zhang, Linlin Gong, et al
Volume: 11
Issue: 9
Pages: e0163622
DOI: https://dx.plos.org/10.1371/journal.pone.0163622
Publisher URL: http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163622
Scopus: 84991727510
Mendeley: http://www.mendeley.com/research/quantitative-proteomic-profiling-molecular-signatures-annexin-a5-lung-squamous-carcinoma-cells

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Mendeley 908 May 05:37 UTC

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{"title"=>"Quantitative proteomic profiling the molecular signatures of annexin A5 in lung squamous carcinoma cells", "type"=>"journal", "authors"=>[{"first_name"=>"Bing", "last_name"=>"Sun", "scopus_author_id"=>"56107770900"}, {"first_name"=>"Yuxin", "last_name"=>"Bai", "scopus_author_id"=>"57199403730"}, {"first_name"=>"Liyuan", "last_name"=>"Zhang", "scopus_author_id"=>"44161552300"}, {"first_name"=>"Linlin", "last_name"=>"Gong", "scopus_author_id"=>"8247253600"}, {"first_name"=>"Xiaoyu", "last_name"=>"Qi", "scopus_author_id"=>"55614451200"}, {"first_name"=>"Huizhen", "last_name"=>"Li", "scopus_author_id"=>"57191579040"}, {"first_name"=>"Faming", "last_name"=>"Wang", "scopus_author_id"=>"57190688111"}, {"first_name"=>"Xinming", "last_name"=>"Chi", "scopus_author_id"=>"56107793800"}, {"first_name"=>"Yulin", "last_name"=>"Jiang", "scopus_author_id"=>"57191572194"}, {"first_name"=>"Shujuan", "last_name"=>"Shao", "scopus_author_id"=>"7102636504"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "sgr"=>"84991727510", "doi"=>"10.1371/journal.pone.0163622", "scopus"=>"2-s2.0-84991727510", "pmid"=>"27684953", "pui"=>"612795420"}, "id"=>"fe21ca3e-f68a-31e0-95d2-c7a59b780964", "abstract"=>"Lung cancer remains the leading cancer killer around the world. It's crucial to identify newer mechanism-based targets to effectively manage lung cancer. Annexin A5 (ANXA5) is a protein kinase C inhibitory protein and calcium dependent phospholipid-binding protein, which may act as an endogenous regulator of various pathophysiological processes. However, its molecular mechanism in lung cancer remains poorly understood. This study was designed to determine the mechanism of ANXA5 in lung cancer with a hope to obtain useful information to provide a new therapeutic target. We used a stable isotope dimethyl labeling based quantitative proteomic method to identify differentially expressed proteins in NSCLC cell lines after ANXA5 transfection. Out of 314 proteins, we identified 26 and 44 proteins that were down- and up-regulated upon ANXA5 modulation, respectively. The IPA analysis revealed that glycolysis and gluconeogenesis were the predominant pathways modulated by ANXA5. Multiple central nodes, namely HSPA5, FN1, PDIA6, ENO1, ALDOA, JUP and KRT6A appeared to occupy regulatory nodes in the protein-protein networks upon ANXA5 modulation. Taken together, ANXA5 appears to have pleotropic effects, as it modulates multiple key signaling pathways, supporting the potential usefulness of ANXA5 as a potential target in lung cancer. This study might provide a new insight into the mechanism of ANXA5 in lung cancer.", "link"=>"http://www.mendeley.com/research/quantitative-proteomic-profiling-molecular-signatures-annexin-a5-lung-squamous-carcinoma-cells", "reader_count"=>8, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>1}

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Web of Science®14 Apr 06:24 UTC

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