Levosimendan Administration in Limb Ischemia: Multicomponent Signaling Serving Kidney Protection
Publication Date
September 29, 2016
Journal
PLOS ONE
Authors
Peter Onody, Peter Aranyi, Zsolt Turoczi, Rita Stangl, et al
Volume
11
Issue
9
Pages
e0163675
DOI
https://dx.plos.org/10.1371/journal.pone.0163675
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0163675
Scopus
84991608346
Mendeley
http://www.mendeley.com/research/levosimendan-administration-limb-ischemia-multicomponent-signaling-serving-kidney-protection
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Mendeley | Further Information

{"title"=>"Levosimendan administration in limb ischemia: Multicomponent signaling serving kidney protection", "type"=>"journal", "authors"=>[{"first_name"=>"Peter", "last_name"=>"Onody", "scopus_author_id"=>"55618869700"}, {"first_name"=>"Peter", "last_name"=>"Aranyi", "scopus_author_id"=>"56116885600"}, {"first_name"=>"Zsolt", "last_name"=>"Turoczi", "scopus_author_id"=>"37004865500"}, {"first_name"=>"Rita", "last_name"=>"Stangl", "scopus_author_id"=>"22939324900"}, {"first_name"=>"Andras", "last_name"=>"Fulop", "scopus_author_id"=>"55891803400"}, {"first_name"=>"Emese", "last_name"=>"Dudas", "scopus_author_id"=>"57191577933"}, {"first_name"=>"Gabor", "last_name"=>"Lotz", "scopus_author_id"=>"7003972483"}, {"first_name"=>"Attila", "last_name"=>"Szijarto", "scopus_author_id"=>"12241914300"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"27684548", "doi"=>"10.1371/journal.pone.0163675", "sgr"=>"84991608346", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-84991608346", "issn"=>"19326203", "pui"=>"612795362"}, "id"=>"0677471f-b116-3808-94e3-d21b94ea54f9", "abstract"=>"Aims and Objectives Acute renal failure is a severe complication of lower extremity major arterial reconstructions, which could even be fatal. Levosimendan is a dual-acting positive inotropic and vasodilatory agent, which is suspected to have protective effects against cardiac ischemia. However, there is no data available on lower limb or remote organ ischemic injuries therefore the aim of the study was to investigate the effect of levosimendan on lower limb ischemia- reperfusion injury and the corollary renal dysfunction. Methods Male Wistar rats underwent 180 min bilateral lower limb ischemia followed by 4 or 24 hours of reperfusion. Intravenous Levosimendan was administered continuously (0.2μg/bwkg/ min) throughout the whole course of ischemia and the first 3h of reperfusion. Results were compared with sham-operated and ischemia-reperfusion groups. Hemodynamic monitoring was performed by invasive arterial blood pressure measurement. Kidney and lower limb muscle microcirculation was registered by a laser Doppler flowmeter. After 4h and 24h of reperfusion, serum, urine and histological samples were collected. Results Systemic hemodynamic parameters and microcirculation of kidney and the lower limb significantly improved in the Levosimendan treated group. Muscle viability was significantly preserved 4 and 24 hours after reperfusion. At the same time, renal functional laboratory tests and kidney histology demonstrated significantly less expressive kidney injury in Levosimendan groups. TNF-α levels were significantly less elevated in the Levosimendan group 4 hours after reperfusion. Conclusion The results claim a protective role for Levosimendan administration during major vascular surgeries to prevent renal complications.", "link"=>"http://www.mendeley.com/research/levosimendan-administration-limb-ischemia-multicomponent-signaling-serving-kidney-protection", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Other"=>3}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>1, "Other"=>3}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>1}

Scopus | Further Information

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