Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis
Publication Date
October 14, 2016
Journal
PLOS ONE
Authors
Gülsenay Citirak, Sanja Cejvanovic, Henning Andersen & John Vissing
Volume
11
Issue
10
Pages
e0164092
DOI
https://dx.plos.org/10.1371/journal.pone.0164092
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0164092
Scopus
84992365970
Mendeley
http://www.mendeley.com/research/effect-gender-disease-duration-treatment-muscle-strength-myasthenia-gravis-1
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Mendeley | Further Information

{"title"=>"Effect of Gender, Disease Duration and Treatment on Muscle Strength in Myasthenia Gravis.", "type"=>"journal", "authors"=>[{"first_name"=>"Gülsenay", "last_name"=>"Citirak"}, {"first_name"=>"Sanja", "last_name"=>"Cejvanovic"}, {"first_name"=>"Henning", "last_name"=>"Andersen"}, {"first_name"=>"John", "last_name"=>"Vissing"}], "year"=>2016, "source"=>"PloS one", "identifiers"=>{"pmid"=>"27741232", "doi"=>"10.1371/journal.pone.0164092", "pui"=>"612829039", "issn"=>"1932-6203", "sgr"=>"84992365970"}, "id"=>"298c80f8-99ba-3594-ab18-d2c30f3d884a", "abstract"=>"INTRODUCTION The aim of this observational, cross-sectional study was to quantify the potential presence of muscle weakness among patients with generalized myasthenia gravis (gMG). The influence of gender, treatment intensity and disease duration on muscle strength and disease progression was also assessed. METHODS Muscle strength was tested in 8 muscle groups by manual muscle testing and by hand-held dynamometry in 107 patients with gMG and 89 healthy age- and gender-matched controls. Disease duration, severity and treatment history were reviewed and compared with muscle strength. RESULTS Patients had reduced strength in all tested muscle group compared to control subjects (p<0.05). Women with gMG were stronger than men (decrease in strength 22.6% vs. 32.7% in men, P<0.05). Regional differences in muscle weakness were also evident, with proximal muscles being more affected. Interestingly, muscle strength did not correlate with disease duration and treatment intensity. CONCLUSIONS The results of this study show that in patients with gMG; 1) there is significant muscle weakness, 2) muscle weakness is more pronounced in men than women, 3) shoulder abductors, hip flexors, and neck muscles are the most affected muscle groups and 4) disease duration or treatment intensity alone are not predictors of loss of muscle strength in gMG.", "link"=>"http://www.mendeley.com/research/effect-gender-disease-duration-treatment-muscle-strength-myasthenia-gravis-1", "reader_count"=>5, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>1, "Medicine and Dentistry"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}}, "group_count"=>1}

Scopus | Further Information

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