Downregulation of Blood Monocyte HLA-DR in ICU Patients Is Also Present in Bone Marrow Cells
Publication Date
November 28, 2016
Authors
Valérie Faivre, Anne Claire Lukaszewicz & Didier Payen
Volume
11
Issue
11
Pages
e0164489
DOI
https://dx.plos.org/10.1371/journal.pone.0164489
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0164489
Scopus
84999018337
Mendeley
http://www.mendeley.com/research/downregulation-blood-monocyte-hladr-icu-patients-also-present-bone-marrow-cells-2
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Mendeley | Further Information

{"title"=>"Downregulation of blood monocyte HLA-DR in ICU patients is also present in bone marrow cells", "type"=>"journal", "authors"=>[{"first_name"=>"Val�rie", "last_name"=>"Faivre", "scopus_author_id"=>"6701728595"}, {"first_name"=>"Anne Claire", "last_name"=>"Lukaszewicz", "scopus_author_id"=>"6602162273"}, {"first_name"=>"Didier", "last_name"=>"Payen", "scopus_author_id"=>"7006023756"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84999018337", "pmid"=>"27893741", "pui"=>"613432143", "scopus"=>"2-s2.0-84999018337", "doi"=>"10.1371/journal.pone.0164489", "issn"=>"19326203"}, "id"=>"0c062ca0-4676-3630-906a-a778577c076a", "abstract"=>"© 2016 Faivre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Background The downregulation of blood monocyte HLA-DR expression also occurs in tissue infiltrative cells in a context of acute clinical inflammation, especially sepsis. This context favors the development of secondary infections and results from various mechanisms. Little is known about HLA-DR expression on bone marrow (BM) cells of the monocyte lineage, the source of circulating monocytes. This study analyzed the BM HLA-DR expression in ICU patients compared to BM monocytes from non-ICU patients and to blood monocytes of control healthy donors. A potential dysfunction of myeloid differentiation was investigated in a subpopulation of these ICU patients to characterize the phenotype of the immature forms of monocytes and granulocytes in BM. Methods and Findings BM and blood were drawn from 33 ICU and 9 non-ICU patients having a BM analysis to precise the etiology of abnormal low count in blood cells. The data were compared with blood cells of 28 control donors. Flow cytometry was used for both HLA-DR expression and phenotyping of immature forms of monocytes and granulocytes. HLA-DR expression was downregulated in both blood and BM monocyte in ICU patients compared to BM of non-ICU patients and blood of control donors. Amplitude of HLA-DR downregulation was comparable in septic and non-septic ICU patients. The phenotype of immature forms of monocytes and granulocytes in BM (n = 11) did not show abnormal myeloid (monocyte + granulocyte) differentiation. Conclusion The downregulation of HLA-DR in BM monocyte lineage is present in ICU patients without major changes in myeloid cells. It may result from a regulation mediated by soluble and/or neuro-endocrine factors present in BM cell microenvironment.", "link"=>"http://www.mendeley.com/research/downregulation-blood-monocyte-hladr-icu-patients-also-present-bone-marrow-cells-2", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Master"=>1, "Student > Postgraduate"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Master"=>1, "Student > Postgraduate"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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