Study of the Ability of Bifidobacteria of Human Origin to Prevent and Treat Rotavirus Infection Using Colonic Cell and Mouse Models
Publication Date
October 11, 2016
Journal
PLOS ONE
Authors
Mélanie Gagnon, Allison Vimont, André Darveau, Ismaïl Fliss, et al
Volume
11
Issue
10
Pages
e0164512
DOI
https://dx.plos.org/10.1371/journal.pone.0164512
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0164512
Scopus
84991466894
Mendeley
http://www.mendeley.com/research/study-ability-bifidobacteria-human-origin-prevent-treat-rotavirus-infection-using-colonic-cell-mouse
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Mendeley | Further Information

{"title"=>"Study of the ability of bifidobacteria of human origin to prevent and treat rotavirus infection using colonic cell and mouse models", "type"=>"journal", "authors"=>[{"first_name"=>"Mealanie", "last_name"=>"Gagnon", "scopus_author_id"=>"7102047361"}, {"first_name"=>"Allison", "last_name"=>"Vimont", "scopus_author_id"=>"56421929200"}, {"first_name"=>"André", "last_name"=>"Darveau", "scopus_author_id"=>"7003953111"}, {"first_name"=>"Ismaïl", "last_name"=>"Fliss", "scopus_author_id"=>"7004209857"}, {"first_name"=>"Julie", "last_name"=>"Jean", "scopus_author_id"=>"7101826282"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "isbn"=>"1932-6203", "pui"=>"612655935", "sgr"=>"84991466894", "doi"=>"10.1371/journal.pone.0164512", "scopus"=>"2-s2.0-84991466894", "pmid"=>"27727323"}, "id"=>"e9f9a3f8-4402-3e52-87a6-091db7780552", "abstract"=>"Rotavirus is the leading cause of severe acute gastroenteritis among children worldwide. Despite effective vaccines, inexpensive alternatives such as probiotics are needed. The aim of this study was to assess the ability of probiotic candidate Bifidobacterium thermophilum RBL67 to inhibit rotavirus infection. Bacterial adhesion to intestinal cells and interference with viral attachment were evaluated in vitro. B. thermophilum RBL67 displayed adhesion indexes of 625 +/- 84 and 1958 +/- 318 on Caco-2 and HT-29 cells respectively and was comparable or superior to four other bifidobacteria, including B. longum ATCC 15707 and B. pseudolongum ATCC 25526 strains. Incubation of B. thermophilum RBL67 for 30 min before (exclusion) and simultaneously (competition) with human rotavirus strain Wa decreased virus attachment by 2.0 +/- 0.1 and 1.5 +/- 0.1 log10 (by 99.0% and 96.8% respectively). Displacement of virus already present was negligible. In CD-1 suckling mice fed B. thermophilum RBL67 challenged with simian rotavirus SA-11, pre-infection feeding with RBL 67 was more effective than post-infection feeding, reducing the duration of diarrhea, limiting epithelial lesions, reducing viral replication in the intestine, accelerating recovery, and stimulating the humoral specific IgG and IgM response, without inducing any adverse effect. B. thermophilum RBL67 had little effect on intestinal IgA titer. These results suggest that humoral immunoglobulin might provide protection against the virus and that B. thermophilum RBL67 has potential as a probiotic able to inhibit rotavirus infection and ultimately reduce its spread.", "link"=>"http://www.mendeley.com/research/study-ability-bifidobacteria-human-origin-prevent-treat-rotavirus-infection-using-colonic-cell-mouse", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Immunology and Microbiology"=>4, "Economics, Econometrics and Finance"=>1}, "reader_count_by_subdiscipline"=>{"Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "reader_count_by_country"=>{"Denmark"=>1}, "group_count"=>0}

Scopus | Further Information

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