Computational Analysis of G-Quadruplex Forming Sequences across Chromosomes Reveals High Density Patterns Near the Terminal Ends
Publication Date
October 24, 2016
Journal
PLOS ONE
Authors
Julia H. Chariker, Donald M. Miller & Eric C. Rouchka
Volume
11
Issue
10
Pages
e0165101
DOI
https://dx.plos.org/10.1371/journal.pone.0165101
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165101
Scopus
84992316259
Mendeley
http://www.mendeley.com/research/computational-analysis-gquadruplex-forming-sequences-across-chromosomes-reveals-high-density-pattern
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Mendeley | Further Information

{"title"=>"Computational analysis of G-quadruplex forming sequences across chromosomes reveals high density patterns near the terminal ends", "type"=>"journal", "authors"=>[{"first_name"=>"Julia H.", "last_name"=>"Chariker", "scopus_author_id"=>"6506003994"}, {"first_name"=>"Donald M.", "last_name"=>"Miller", "scopus_author_id"=>"57190537592"}, {"first_name"=>"Eric C.", "last_name"=>"Rouchka", "scopus_author_id"=>"6507535742"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"612881039", "sgr"=>"84992316259", "issn"=>"19326203", "pmid"=>"27776185", "scopus"=>"2-s2.0-84992316259", "doi"=>"10.1371/journal.pone.0165101", "isbn"=>"1932-6203"}, "id"=>"75c9bf22-64cf-36a2-a760-6db09e446668", "abstract"=>"G-quadruplex structures (G4) are found throughout the human genome and are known to play a regulatory role in a variety of molecular processes. Structurally, they have many configurations and can form from one or more DNA strands. At the gene level, they regulate gene expression and protein synthesis. In this paper, chromosomal-level patterns of distribution are analyzed on the human genome to identify high-level distribution patterns potentially related to global functional processes. Here we show unique high density banding patterns on individual chromosomes that are highly correlated, appearing in a mirror pattern, across forward and reverse DNA strands. The highest density of G4 sequences occurs within four megabases of one end of most chromosomes and contains G4 motifs that bind with zinc finger proteins. These findings suggest that G4 may play a role in global chromosomal processes such as those found in meiosis.", "link"=>"http://www.mendeley.com/research/computational-analysis-gquadruplex-forming-sequences-across-chromosomes-reveals-high-density-pattern", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Professor > Associate Professor"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>5, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>5, "Computer Science"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Computer Science"=>{"Computer Science"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>3}}, "reader_count_by_country"=>{"Korea (South)"=>1, "Switzerland"=>1}, "group_count"=>0}

Scopus | Further Information

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