Prognostic Importance of Dyspnea for Cardiovascular Outcomes and Mortality in Persons without Prevalent Cardiopulmonary Disease: The Atherosclerosis Risk in Communities Study
Publication Date
October 25, 2016
Journal
PLOS ONE
Authors
Mario Santos, Dalane W. Kitzman, Kunihiro Matsushita, Laura Loehr, et al
Volume
11
Issue
10
Pages
e0165111
DOI
https://dx.plos.org/10.1371/journal.pone.0165111
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165111
Scopus
84992426995
Mendeley
http://www.mendeley.com/research/prognostic-importance-dyspnea-cardiovascular-outcomes-mortality-persons-without-prevalent-cardiopulm
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Mendeley | Further Information

{"title"=>"Prognostic importance of dyspnea for cardiovascular outcomes and mortality in persons without prevalent cardiopulmonary disease: The atherosclerosis risk in communities study", "type"=>"journal", "authors"=>[{"first_name"=>"Mario", "last_name"=>"Santos", "scopus_author_id"=>"55933626800"}, {"first_name"=>"Dalane W.", "last_name"=>"Kitzman", "scopus_author_id"=>"35401432700"}, {"first_name"=>"Kunihiro", "last_name"=>"Matsushita", "scopus_author_id"=>"7201771873"}, {"first_name"=>"Laura", "last_name"=>"Loehr", "scopus_author_id"=>"16177848600"}, {"first_name"=>"Carla A.", "last_name"=>"Sueta", "scopus_author_id"=>"57188954999"}, {"first_name"=>"Amil M.", "last_name"=>"Shah", "scopus_author_id"=>"7403209851"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84992426995", "scopus"=>"2-s2.0-84992426995", "pui"=>"612904477", "pmid"=>"27780208", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0165111"}, "id"=>"76e580bb-fc63-3fa5-8021-6365fc5900f8", "abstract"=>"BACKGROUND: The relationship between dyspnea and incident heart failure (HF) and myocardial infarction (MI) among patients without previously diagnosed cardiopulmonary disease is unclear. We studied the prognostic relevance of self-reported dyspnea for cardiovascular outcomes and all-cause mortality in persons without previously diagnosed cardiopulmonary disease. METHODS AND RESULTS: We studied 10 881 community-dwelling participants (mean age 57+/-6, 56% women, 25% black) who were free of prevalent cardiopulmonary disease from Atherosclerosis Risk in Communities Study. Dyspnea status at study entry using the modified Medical Research Council (mMRC) scale. The primary outcomes were time to HF, MI or all-cause death. Dyspnea prevalence was 22%, and was mild (mMRC grade 1 or 2) in 21% and moderate-to-severe (mMRC 3 or 4) in 1%. The main correlates of dyspnea were older age, female sex, higher BMI and active smoking. Over a follow-up of 19+/-5 years, greater self-reported dyspnea severity was associated with worse prognosis. Mild dyspnea was associated with significantly heightened risk of HF (adjusted Hazard Ratio, HR,1.30; 95% CI: 1.16-1.46), MI (adjusted HR 1.34; 95%CI: 1.20-1.50), and death (adjusted HR 1.16; 95%CI: 1.06-1.26), with moderate/severe dyspnea associated with an even greater risk (adjusted HR 2.14, 95%CI: 1.59-2.89; 1.93, 95%CI: 1.41-2.56; 1.96, 95%CI: 1.55-2.48, respectively). CONCLUSION: In community-dwelling persons free of previously diagnosed cardiopulmonary disease, self-reported dyspnea is common and, even when of mild intensity, it is independently associated with a greater risk of incident HF, MI, and death. Our data emphasize the prognostic importance of even mild self-reported dyspnea for cardiovascular outcomes.", "link"=>"http://www.mendeley.com/research/prognostic-importance-dyspnea-cardiovascular-outcomes-mortality-persons-without-prevalent-cardiopulm", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Other"=>2, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Researcher"=>1, "Other"=>2, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Nursing and Health Professions"=>1, "Agricultural and Biological Sciences"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>2}

Scopus | Further Information

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