Phenotype and Function of CD209+ Bovine Blood Dendritic Cells, Monocyte-Derived-Dendritic Cells and Monocyte-Derived Macrophages
Publication Date
October 20, 2016
Journal
PLOS ONE
Authors
Kun Taek Park, Mahmoud M. El Naggar, Gaber S. Abdellrazeq, John P. Bannantine, et al
Volume
11
Issue
10
Pages
e0165247
DOI
https://dx.plos.org/10.1371/journal.pone.0165247
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165247
Web of Science
000386204500140
Scopus
84992126952
Mendeley
http://www.mendeley.com/research/phenotype-function-cd209-bovine-blood-dendritic-cells-monocytederiveddendritic-cells-monocytederived
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Mendeley | Further Information

{"title"=>"Phenotype and function of CD209+ bovine blood dendritic cells, monocyte-derived-dendritic cells and monocyte-derived macrophages", "type"=>"journal", "authors"=>[{"first_name"=>"Kun Taek", "last_name"=>"Park", "scopus_author_id"=>"56164627000"}, {"first_name"=>"Mahmoud M.", "last_name"=>"ElNaggar", "scopus_author_id"=>"57125951100"}, {"first_name"=>"Gaber S.", "last_name"=>"Abdellrazeq", "scopus_author_id"=>"37070215900"}, {"first_name"=>"John P.", "last_name"=>"Bannantine", "scopus_author_id"=>"7004617321"}, {"first_name"=>"Victoria", "last_name"=>"Mack", "scopus_author_id"=>"57190254226"}, {"first_name"=>"Lindsay M.", "last_name"=>"Fry", "scopus_author_id"=>"56806463200"}, {"first_name"=>"William C.", "last_name"=>"Davis", "scopus_author_id"=>"7402807163"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"612830896", "sgr"=>"84992126952", "issn"=>"19326203", "pmid"=>"27764236", "scopus"=>"2-s2.0-84992126952", "doi"=>"10.1371/journal.pone.0165247"}, "id"=>"227deb24-d5e3-3810-aba0-7797f2c3fca7", "abstract"=>"Phylogenic comparisons of the mononuclear phagocyte system (MPS) of humans and mice demonstrate phenotypic divergence of dendritic cell (DC) subsets that play similar roles in innate and adaptive immunity. Although differing in phenotype, DC can be classified into four groups according to ontogeny and function: conventional DC (cDC1 and cDC2), plasmacytoid DC (pDC), and monocyte derived DC (MoDC). DC of Artiodactyla (pigs and ruminants) can also be sub-classified using this system, allowing direct functional and phenotypic comparison of MoDC and other DC subsets trafficking in blood (bDC). Because of the high volume of blood collections required to study DC, cattle offer the best opportunity to further our understanding of bDC and MoDC function in an outbred large animal species. As reported here, phenotyping DC using a monoclonal antibody (mAb) to CD209 revealed CD209 is expressed on the major myeloid population of DC present in blood and MoDC, providing a phenotypic link between these two subsets. Additionally, the present study demonstrates that CD209 is also expressed on monocyte derived macrophages (MoΦ). Functional analysis revealed each of these populations can take up and process antigens (Ags), present them to CD4 and CD8 T cells, and elicit a T-cell recall response. Thus, bDC, MoDC, and MoΦ pulsed with pathogens or candidate vaccine antigens can be used to study factors that modulate DC-driven T-cell priming and differentiation ex vivo.", "link"=>"http://www.mendeley.com/research/phenotype-function-cd209-bovine-blood-dendritic-cells-monocytederiveddendritic-cells-monocytederived", "reader_count"=>11, "reader_count_by_academic_status"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1, "Professor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>3, "Student > Ph. D. Student"=>3, "Student > Master"=>2, "Other"=>1, "Professor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>5, "Veterinary Science and Veterinary Medicine"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>1}

Scopus | Further Information

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