EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy
Publication Date
October 27, 2016
Journal
PLOS ONE
Authors
Catarina Oliveira Silva, Steffen B. Petersen, Catarina Pinto Reis, Patrícia Rijo, et al
Volume
11
Issue
10
Pages
e0165419
DOI
https://dx.plos.org/10.1371/journal.pone.0165419
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165419
Scopus
84992755798
Mendeley
http://www.mendeley.com/research/egf-functionalized-polymercoated-gold-nanoparticles-promote-egf-photostability-egfr-internalization
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Mendeley | Further Information

{"title"=>"EGF functionalized polymer-coated gold nanoparticles promote EGF photostability and EGFR internalization for photothermal therapy", "type"=>"journal", "authors"=>[{"first_name"=>"Catarina Oliveira", "last_name"=>"Silva", "scopus_author_id"=>"57189448949"}, {"first_name"=>"Steffen B.", "last_name"=>"Petersen", "scopus_author_id"=>"57191537596"}, {"first_name"=>"Catarina Pinto", "last_name"=>"Reis", "scopus_author_id"=>"14027161300"}, {"first_name"=>"Patrícia", "last_name"=>"Rijo", "scopus_author_id"=>"8600601700"}, {"first_name"=>"Jesús", "last_name"=>"Molpeceres", "scopus_author_id"=>"6701736671"}, {"first_name"=>"Ana Sofia", "last_name"=>"Fernandes", "scopus_author_id"=>"55937368100"}, {"first_name"=>"Odete", "last_name"=>"Gonçalves", "scopus_author_id"=>"29467560300"}, {"first_name"=>"Andreia C.", "last_name"=>"Gomes", "scopus_author_id"=>"36840847300"}, {"first_name"=>"Isabel", "last_name"=>"Correia", "scopus_author_id"=>"7003557498"}, {"first_name"=>"Henrik", "last_name"=>"Vorum", "scopus_author_id"=>"7006971449"}, {"first_name"=>"Maria Teresa", "last_name"=>"Neves-Petersen", "scopus_author_id"=>"6602972630"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "doi"=>"10.1371/journal.pone.0165419", "sgr"=>"84992755798", "scopus"=>"2-s2.0-84992755798", "pmid"=>"27788212", "pui"=>"612931760"}, "id"=>"f5359b61-f335-3e49-8935-e5be732d7fdd", "abstract"=>"The application of functionalized nanocarriers on photothermal therapy for cancer ablation has wide interest. The success of this application depends on the therapeutic efficiency and biocompatibility of the system, but also on the stability and biorecognition of the conjugated protein. This study aims at investigating the hypothesis that EGF functionalized polymer-coated gold nanoparticles promote EGF photostability and EGFR internalization, making these conjugated particles suitable for photothermal therapy. The conjugated gold nanoparticles (100-200 nm) showed a plasmon absorption band located within the near-infrared range (650-900 nm), optimal for photothermal therapy applications. The effects of temperature, of polymer-coated gold nanoparticles and of UVB light (295nm) on the fluorescence properties of EGF have been investigated with steady-state and time-resolved fluorescence spectroscopy. The fluorescence properties of EGF, including the formation of Trp and Tyr photoproducts, is modulated by temperature and by the intensity of the excitation light. The presence of polymeric-coated gold nanoparticles reduced or even avoided the formation of Trp and Tyr photoproducts when EGF is exposed to UVB light, protecting this way the structure and function of EGF. Cytotoxicity studies of conjugated nanoparticles carried out in normal-like human keratinocytes showed small, concentration dependent decreases in cell viability (0-25%). Moreover, conjugated nanoparticles could activate and induce the internalization of overexpressed Epidermal Growth Factor Receptor in human lung carcinoma cells. In conclusion, the gold nanoparticles conjugated with Epidermal Growth Factor and coated with biopolymers developed in this work, show a potential application for near infrared photothermal therapy, which may efficiently destroy solid tumours, reducing the damage of the healthy tissue.", "link"=>"http://www.mendeley.com/research/egf-functionalized-polymercoated-gold-nanoparticles-promote-egf-photostability-egfr-internalization", "reader_count"=>26, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>3, "Librarian"=>2, "Researcher"=>2, "Student > Ph. D. Student"=>7, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>2, "Student > Bachelor"=>1, "Professor"=>3}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1, "Materials Science"=>3, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>4, "Pharmacology, Toxicology and Pharmaceutical Science"=>6, "Chemistry"=>5, "Social Sciences"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Materials Science"=>{"Materials Science"=>3}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Chemistry"=>{"Chemistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>6}}, "group_count"=>2}

Scopus | Further Information

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