Clinical and Laboratory Differences between Lymphocyte- and Neutrophil-Predominant Pleural Tuberculosis
Publication Date
October 27, 2016
Journal
PLOS ONE
Authors
Hayoung Choi, Hae Ri Chon, Kang Kim, Sukyeon Kim, et al
Volume
11
Issue
10
Pages
e0165428
DOI
https://dx.plos.org/10.1371/journal.pone.0165428
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165428
Scopus
84992741429
Mendeley
http://www.mendeley.com/research/clinical-laboratory-differences-between-lymphocyte-neutrophilpredominant-pleural-tuberculosis
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Mendeley | Further Information

{"title"=>"Clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural tuberculosis", "type"=>"journal", "authors"=>[{"first_name"=>"Hayoung", "last_name"=>"Choi", "scopus_author_id"=>"57191752334"}, {"first_name"=>"Hae Ri", "last_name"=>"Chon", "scopus_author_id"=>"56686175200"}, {"first_name"=>"Kang", "last_name"=>"Kim", "scopus_author_id"=>"56235940400"}, {"first_name"=>"Sukyeon", "last_name"=>"Kim", "scopus_author_id"=>"57104496400"}, {"first_name"=>"Ki Jong", "last_name"=>"Oh", "scopus_author_id"=>"57191748515"}, {"first_name"=>"Suk Hyeon", "last_name"=>"Jeong", "scopus_author_id"=>"56398835900"}, {"first_name"=>"Woo Jin", "last_name"=>"Jung", "scopus_author_id"=>"57191755945"}, {"first_name"=>"Beomsu", "last_name"=>"Shin", "scopus_author_id"=>"55991888700"}, {"first_name"=>"Byung Woo", "last_name"=>"Jhun", "scopus_author_id"=>"54381931700"}, {"first_name"=>"Hyun", "last_name"=>"Lee", "scopus_author_id"=>"56152136400"}, {"first_name"=>"Hye Yun", "last_name"=>"Park", "scopus_author_id"=>"14829210000"}, {"first_name"=>"Won Jung", "last_name"=>"Koh", "scopus_author_id"=>"7102038874"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-84992741429", "sgr"=>"84992741429", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0165428", "pui"=>"612931866", "pmid"=>"27788218"}, "id"=>"f9d247cc-3ca3-3730-bb82-d94e651aa9e3", "abstract"=>"Pleural tuberculosis (TB), a form of extrapulmonary TB, can be difficult to diagnose. High numbers of lymphocytes in pleural fluid have been considered part of the diagnostic criteria for pleural TB; however, in many cases, neutrophils rather than lymphocytes are the predominant cell type in pleural effusions, making diagnosis more complicated. Additionally, there is limited information on the clinical and laboratory characteristics of neutrophil-predominant pleural effusions caused by Mycobacterium tuberculosis (MTB). To investigate clinical and laboratory differences between lymphocyte- and neutrophil-predominant pleural TB, we retrospectively analyzed 200 patients with the two types of pleural TB. Of these patients, 9.5% had neutrophil-predominant pleural TB. Patients with lymphocyte-predominant and neutrophil-predominant pleural TB showed similar clinical signs and symptoms. However, neutrophil-predominant pleural TB was associated with significantly higher inflammatory serum markers, such as white blood cell count (P = 0.001) and C-reactive protein (P = 0.001). Moreover, MTB was more frequently detected in the pleural fluid from patients in the neutrophil-predominant group than the lymphocyte-predominant group, with the former group exhibiting significantly higher rates of positive results for acid-fast bacilli in sputum (36.8 versus 9.4%, P = 0.003), diagnostic yield of MTB culture (78.9% versus 22.7%, P < 0.001) and MTB detected by polymerase chain reaction (31.6% versus 5.0%, P = 0.001). Four of seven patients with repeated pleural fluid analyses revealed persistent neutrophil-predominant features, which does not support the traditional viewpoint that neutrophil-predominant pleural TB is a temporary form that rapidly develops into lymphocyte-predominant pleural TB. In conclusion, neutrophil-predominant pleural TB showed a more intense inflammatory response and a higher positive rate in microbiological testing compared to lymphocyte-predominant pleural TB. Pleural TB should be considered in neutrophil-predominant pleural effusions, and microbiological tests are warranted.", "link"=>"http://www.mendeley.com/research/clinical-laboratory-differences-between-lymphocyte-neutrophilpredominant-pleural-tuberculosis", "reader_count"=>6, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>4, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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