HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats
Publication Date
October 27, 2016
Journal
PLOS ONE
Authors
Karolina Pytka, Monika Głuch Lutwin, Joanna Knutelska, Magdalena Jakubczyk, et al
Volume
11
Issue
10
Pages
e0165495
DOI
https://dx.plos.org/10.1371/journal.pone.0165495
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165495
Scopus
84992731101
Mendeley
http://www.mendeley.com/research/hbk14-hbk15-not-influence-blood-pressure-lipid-profile-glucose-level-liver-enzymes-activity-after-ch-1
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Mendeley | Further Information

{"title"=>"HBK-14 and HBK-15 do not influence blood pressure, lipid profile, glucose level, or liver enzymes activity after chronic treatment in rats", "type"=>"journal", "authors"=>[{"first_name"=>"Karolina", "last_name"=>"Pytka", "scopus_author_id"=>"35387030200"}, {"first_name"=>"Monika", "last_name"=>"Głuch-Lutwin", "scopus_author_id"=>"55883724200"}, {"first_name"=>"Joanna", "last_name"=>"Knutelska", "scopus_author_id"=>"55847557000"}, {"first_name"=>"Magdalena", "last_name"=>"Jakubczyk", "scopus_author_id"=>"57191750647"}, {"first_name"=>"Anna", "last_name"=>"Waszkielewicz", "scopus_author_id"=>"12783617900"}, {"first_name"=>"Magdalena", "last_name"=>"Kotańska", "scopus_author_id"=>"57191290702"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84992731101", "pmid"=>"27788267", "pui"=>"612931835", "issn"=>"19326203", "scopus"=>"2-s2.0-84992731101", "doi"=>"10.1371/journal.pone.0165495"}, "id"=>"2a93bcdb-8832-3efe-9ad9-65fe6ffc78c8", "abstract"=>"© 2016 Pytka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Older and even new antidepressants cause adverse effects, such as orthostatic hypotension, hyper- or hypoglycemia, liver injury or lipid disorders. In our previous experiments we showed significant antidepressant- and anxiolytic-like activities of dual 5-HT 1A and 5-HT 7 antagonists with α 1 -adrenolitic properties i.e. 1-[(2,6-dimethylphenoxy)ethoxyethyl]-4-(2- methoxyphenyl)piperazine hydrochloride (HBK-14) and 1-[(2-chloro-6-methylphenoxy) ethoxyethyl] -4-(2-methoxyphenyl)piperazine hydrochloride (HBK-15). Here, we evaluated the influence of chronic administration of HBK-14 and HBK-15 on blood pressure (non-invasive blood pressure measurement system for rodents), lipid profile (total cholesterol, low density lipoproteins-DLDL, high density lipoproteins-DHDL, triglycerides), glucose level, and liver enzymes activity (aspartate aminotransferase, alanine aminotransferase, γ-glutamyl transferase). We determined potential antihistaminic (isolated Guinea pig ileum) and antioxidant properties (ferric reducing ability of plasma-FRAP, non-protein thiols-NPSH, stable free radical diphenylpicrylhydrazyl-DDPPH) cytotoxicity. Our experiments revealed that HBK-14 and HBK-15 did not influence blood pressure, lipid profile, glucose level or liver enzymes activity in rats after 2-week treatment. We also showed that none of the compounds possessed antioxidant or cytotoxic properties at antidepressant- and anxiolytic-like doses. HBK-14 and HBK-15 very weakly blocked H 1 receptors in Guinea pig ileum. Positive results of our preliminary experiments on the safety of HBK-14 and HBK-15 encourage further studies concerning their effectiveness in the treatment of depression and/or anxiety disorders.", "link"=>"http://www.mendeley.com/research/hbk14-hbk15-not-influence-blood-pressure-lipid-profile-glucose-level-liver-enzymes-activity-after-ch-1", "reader_count"=>3, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Ph. D. Student"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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