Somatic Variations in Cervical Cancers in Indian Patients
Publication Date
November 09, 2016
Authors
Poulami Das, Akanksha Bansal, Sudha Narayan Rao, Kedar Deodhar, et al
Volume
11
Issue
11
Pages
e0165878
DOI
https://dx.plos.org/10.1371/journal.pone.0165878
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0165878
Scopus
84994408762
Mendeley
http://www.mendeley.com/research/somatic-variations-cervical-cancers-indian-patients
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Mendeley | Further Information

{"title"=>"Somatic variations in cervical cancers in Indian patients", "type"=>"journal", "authors"=>[{"first_name"=>"Poulami", "last_name"=>"Das", "scopus_author_id"=>"23093733200"}, {"first_name"=>"Akanksha", "last_name"=>"Bansal", "scopus_author_id"=>"57191880339"}, {"first_name"=>"Sudha Narayan", "last_name"=>"Rao", "scopus_author_id"=>"57191883521"}, {"first_name"=>"Kedar", "last_name"=>"Deodhar", "scopus_author_id"=>"7005570350"}, {"first_name"=>"Umesh", "last_name"=>"Mahantshetty", "scopus_author_id"=>"14020182300"}, {"first_name"=>"Shyam K.", "last_name"=>"Shrivastava", "scopus_author_id"=>"35453924100"}, {"first_name"=>"Karthikeyan", "last_name"=>"Sivaraman", "scopus_author_id"=>"57191885222"}, {"first_name"=>"Rita", "last_name"=>"Mulherkar", "scopus_author_id"=>"7004914353"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84994408762", "pui"=>"613146308", "doi"=>"10.1371/journal.pone.0165878", "sgr"=>"84994408762", "pmid"=>"27829003"}, "id"=>"496252eb-733c-315c-9f5c-2364da14203e", "abstract"=>"There are very few reports that describe the mutational landscape of cervical cancer, one of the leading cancers in Indian women. The aim of the present study was to investigate the somatic mutations that occur in cervical cancer. Whole exome sequencing of 10 treatment naïve tumour biopsies with matched blood samples, from a cohort of Indian patients with locally advanced disease, was performed. The data revealed missense mutations across 1282 genes, out of 1831 genes harbouring somatic mutations. These missense mutations (nonsynonymous + stop-gained) when compared with pre-existing mutations in the COSMIC database showed that 272 mutations in 250 genes were already reported although from cancers other than cervical cancer. More than 1000 novel somatic variations were obtained in matched tumour samples. Pathways / genes that are frequently mutated in various other cancers were found to be mutated in cervical cancers. A significant enrichment of somatic mutations in the MAPK pathway was observed, some of which could be potentially targetable. This is the first report of whole exome sequencing of well annotated cervical cancer samples from Indian women and helps identify trends in mutation profiles that are found in an Indian cohort of cervical cancer.", "link"=>"http://www.mendeley.com/research/somatic-variations-cervical-cancers-indian-patients", "reader_count"=>7, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>2, "Veterinary Science and Veterinary Medicine"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

Scopus | Further Information

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