Diagnostic Value and Interreader Agreement of the Pancreaticolienal Gap in Pancreatic Cancer on MDCT
Publication Date
November 28, 2016
Authors
Khoschy Schawkat, Wolfgang Kühn, Daniel Inderbitzin, Beat Gloor, et al
Volume
11
Issue
11
Pages
e0166003
DOI
https://dx.plos.org/10.1371/journal.pone.0166003
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166003
Scopus
84998610756
Mendeley
http://www.mendeley.com/research/diagnostic-value-interreader-agreement-pancreaticolienal-gap-pancreatic-cancer-mdct
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Mendeley | Further Information

{"title"=>"Diagnostic value and interreader agreement of the pancreaticolienal gap in pancreatic cancer on MDCT", "type"=>"journal", "authors"=>[{"first_name"=>"Khoschy", "last_name"=>"Schawkat", "scopus_author_id"=>"57192162716"}, {"first_name"=>"Wolfgang", "last_name"=>"K�hn", "scopus_author_id"=>"57201105400"}, {"first_name"=>"Daniel", "last_name"=>"Inderbitzin", "scopus_author_id"=>"6603552532"}, {"first_name"=>"Beat", "last_name"=>"Gloor", "scopus_author_id"=>"35840084000"}, {"first_name"=>"Johannes T.", "last_name"=>"Heverhagen", "scopus_author_id"=>"7003492670"}, {"first_name"=>"Val Murray", "last_name"=>"Runge", "scopus_author_id"=>"7006548526"}, {"first_name"=>"Andreas", "last_name"=>"Christe", "scopus_author_id"=>"14629950700"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84998610756", "scopus"=>"2-s2.0-84998610756", "pui"=>"613432107", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0166003"}, "id"=>"1ffa162a-a0cc-3fb8-af16-162c014e63eb", "abstract"=>"© 2016 Schawkat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective The aim of this retrospective study was to evaluate the diagnostic value and measure interreader agreement of the pancreaticolienal gap (PLG) in the assessment of imaging features of pancreatic carcinoma (PC) on contrast-enhanced multi-detector computed tomography (CE-MDCT). Materials and Methods CE-MDCT studies in the portal venous phase were retrospectively reviewed for 66 patients with PC. The age- and gender-matched control group comprised 103 healthy individuals. Three radiologists with different levels of experience independently measured the PLG (the minimum distance of the pancreatic tail to the nearest border of the spleen) in the axial plane. The interreader agreement of the PLG and the receiver operating characteristic (ROC) curve was used to calculate the accuracy of the technique. Results While the control group (n = 103) showed a median PLG of 3 mm (Range: 0 - 39mm) the PC patients had a significantly larger PLG of 15mm (Range: 0 - 53mm)(p < 0.0001). A ROC curve demonstrated a cutoff-value of > 12 mm for PC, with a sensitivity of 58.2% (95% CI = 45.5-70.1), specificity of 84.0% (95% CI = 75.6-90.4) and an area under the ROC curve of 0.714 (95% CI = 0.641 to 0.780). The mean interreader agreement showed correlation coefficient r of 0.9159. The extent of the PLG did not correlate with tumor stage but did correlate with pancreatic density (fatty involution) and age, the density decreased by 4.1 HU and the PLG increased by 0.8 mm within every 10 y. Conclusion The significant interreader agreement supports the use of the PLG as a characterizing feature of pancreatic cancer independent of the tumor stage on an axial plane. The increase in the PLG with age may represent physiological atrophy of the pancreatic tail.", "link"=>"http://www.mendeley.com/research/diagnostic-value-interreader-agreement-pancreaticolienal-gap-pancreatic-cancer-mdct", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Postgraduate"=>1, "Other"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Postgraduate"=>1, "Other"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}}, "group_count"=>0}

Scopus | Further Information

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