Uric Acid as a Marker of Mortality and Morbidity in Fabry Disease
Publication Date
November 11, 2016
Authors
Daniel Rob, Josef Marek, Gabriela Dostálová, Lubor Goláň, et al
Volume
11
Issue
11
Pages
e0166290
DOI
https://dx.plos.org/10.1371/journal.pone.0166290
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166290
Web of Science
000387779200035
Scopus
84994748470
Mendeley
http://www.mendeley.com/research/uric-acid-marker-mortality-morbidity-fabry-disease
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Mendeley | Further Information

{"title"=>"Uric acid as a marker of mortality and morbidity in fabry disease", "type"=>"journal", "authors"=>[{"first_name"=>"Daniel", "last_name"=>"Rob", "scopus_author_id"=>"56695069300"}, {"first_name"=>"Josef", "last_name"=>"Marek", "scopus_author_id"=>"57192903908"}, {"first_name"=>"Gabriela", "last_name"=>"Dostálová", "scopus_author_id"=>"24178896400"}, {"first_name"=>"Lubor", "last_name"=>"Goláò", "scopus_author_id"=>"57191909471"}, {"first_name"=>"Aleš", "last_name"=>"Linhart", "scopus_author_id"=>"7004149017"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84994748470", "sgr"=>"84994748470", "pui"=>"613161771", "pmid"=>"27835692", "doi"=>"10.1371/journal.pone.0166290"}, "id"=>"c28425cf-4cc3-3740-b9ab-abb9e557d213", "abstract"=>"BACKGROUND: Serum uric acid (UA) elevation is common in patients with cardiovascular, renal and metabolic diseases. However, no study to date has analysed the role of UA in Fabry disease (FD). OBJECTIVES: To evaluate the association between serum UA levels and mortality and morbidity in FD. MATERIALS AND METHODS: We conducted a post-hoc analysis of a prospectively followed-up cohort of 124 patients with genetically proven FD. Serum UA levels were acquired at baseline; clinical events and mortality were assessed during regular visits every 6 to 12 months. The primary endpoint was a composite of multiple secondary outcomes: all-cause mortality, adverse cardiovascular events, progression of renal dysfunction and stroke or transient ischaemic attack (TIA). Predictive value was assessed using the Cox proportional hazards model and the Kaplan Meyer estimator. RESULTS: During follow-up of 7.4 +/- 3.7 years, 64 (52%) patients reached the primary combined endpoint. Overall, UA levels were significantly associated with combined outcome (p < 0.001) and remained independently associated after correcting for age, sex and estimated glomerular filtration rate (hazard ratio [HR] per 20 mumol/l increase 1.09, 95% confidence interval [95%CI] (1.00-1.19), p = 0.04). UA was associated with overall mortality in univariate analysis (p = 0.021); however, the association did not reach statistical significance after multivariate correction (HR per 20 mumol/l increase 1.07 95%CI 0.93-1.25, p = 0.32). Higher UA levels were also associated with cardiac adverse outcomes, progression of left ventricular hypertrophy and progression of renal dysfunction (ps < 0.001). No association was observed between UA levels and stroke or TIA (p = 0.323). CONCLUSION AND IMPLICATIONS: Increased serum UA levels may represent an independent risk factor for adverse clinical outcomes in Fabry patients and are associated with all-cause mortality. UA is a widely available and cheap biomarker that may improve risk stratification of Fabry patients in clinical practice.", "link"=>"http://www.mendeley.com/research/uric-acid-marker-mortality-morbidity-fabry-disease", "reader_count"=>7, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Other"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Other"=>2, "Student > Bachelor"=>2, "Lecturer > Senior Lecturer"=>1, "Student > Ph. D. Student"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>5, "Neuroscience"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>0}

Scopus | Further Information

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