Gallstones: A Worldwide Multifaceted Disease and Its Correlations with Gallbladder Carcinoma
Publication Date
November 10, 2016
Authors
Raj Kumar Sharma, Kanchan Sonkar, Neeraj Sinha, Pradeep Rebala, et al
Volume
11
Issue
11
Pages
e0166351
DOI
https://dx.plos.org/10.1371/journal.pone.0166351
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166351
Scopus
84994719719
Mendeley
http://www.mendeley.com/research/gallstones-worldwide-multifaceted-disease-correlations-gallbladder-carcinoma
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Mendeley | Further Information

{"title"=>"Gallstones: A worldwide multifaceted disease and its correlations with gallbladder carcinoma", "type"=>"journal", "authors"=>[{"first_name"=>"Raj Kumar", "last_name"=>"Sharma", "scopus_author_id"=>"7407244219"}, {"first_name"=>"Kanchan", "last_name"=>"Sonkar", "scopus_author_id"=>"26659163800"}, {"first_name"=>"Neeraj", "last_name"=>"Sinha", "scopus_author_id"=>"7202706188"}, {"first_name"=>"Pradeep", "last_name"=>"Rebala", "scopus_author_id"=>"35574718100"}, {"first_name"=>"Ahmad Ebrah", "last_name"=>"Albani", "scopus_author_id"=>"57191907771"}, {"first_name"=>"Anu", "last_name"=>"Behari", "scopus_author_id"=>"15767182000"}, {"first_name"=>"Duvvuri Nageshwar", "last_name"=>"Reddy", "scopus_author_id"=>"57191912044"}, {"first_name"=>"Alvina", "last_name"=>"Farooqui", "scopus_author_id"=>"37013012800"}, {"first_name"=>"Vinay Kumar", "last_name"=>"Kapoor", "scopus_author_id"=>"7102101455"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"84994719719", "doi"=>"10.1371/journal.pone.0166351", "scopus"=>"2-s2.0-84994719719", "pui"=>"613147216", "issn"=>"19326203"}, "id"=>"dd34d84f-6e26-3114-af4b-3dc76ce0322a", "abstract"=>"© 2016 Sharma et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Gallstones (GS) associated diseases are among the most recurrent and frequent diseases delineated in India and United Arab Emirates. Several reports suggest that the association of GS with gallbladder cancer (GBC) is very high in Northern part of India; however, its occurrence in UAE and Southern part of India is notably low. Therefore, in the present study, we aimed to perform compositional analysis of GS in three different geographical areas by Solid State Nuclear Magnetic Resonance and Fourier Transformed Infrared spectroscopy. Methods: Natural abundance 13 C cross polarization magic angle spinning Nuclear Magnetic Resonance and Fourier Transform Infrared spectroscopy is employed for the analysis of human gallstone. Results: Cholesterol, bilirubin and calcium carbonate were present in variant concentrations in GS obtained from three different geographical regions. Cholesterol was present predominantly in gallstones from North India. Bilirubin was found to be a main constituent in gallstones pertaining to South India. Whereas GS from UAE showed both cholesterol and bilirubin as their major constituents. Calcium carbonate was found in varying concentrations in gallstones acquired from different regions. Conclusion: Variation in environmental condition and dietary habits may contribute and affect the GS formation. Alterations in bile composition influence the GB and augment the crystallization of cholesterol. Analysis of different geographical regions GS could be an important stride to understand the etiology of GS diseases.", "link"=>"http://www.mendeley.com/research/gallstones-worldwide-multifaceted-disease-correlations-gallbladder-carcinoma", "reader_count"=>2, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>2}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>2}, "reader_count_by_subject_area"=>{"Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "group_count"=>0}

Scopus | Further Information

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