Muscle-Related Polymorphisms (MSTN rs1805086 and ACTN3 rs1815739) Are Not Associated with Exceptional Longevity in Japanese Centenarians
Publication Date
November 18, 2016
Authors
Noriyuki Fuku, Rafael Alis, Thomas Yvert, Hirofumi Zempo, et al
Volume
11
Issue
11
Pages
e0166605
DOI
https://dx.plos.org/10.1371/journal.pone.0166605
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166605
Scopus
84995906211
Mendeley
http://www.mendeley.com/research/musclerelated-polymorphisms-mstn-rs1805086-actn3-rs1815739-not-associated-exceptional-longevity-japa
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Mendeley | Further Information

{"title"=>"Muscle-related polymorphisms (mstn rs1805086 and actn3 rs1815739) are not associated with exceptional longevity in Japanese centenarians", "type"=>"journal", "authors"=>[{"first_name"=>"Noriyuki", "last_name"=>"Fuku", "scopus_author_id"=>"6508346353"}, {"first_name"=>"Rafael", "last_name"=>"Alis", "scopus_author_id"=>"6507215815"}, {"first_name"=>"Thomas", "last_name"=>"Yvert", "scopus_author_id"=>"35747729900"}, {"first_name"=>"Hirofumi", "last_name"=>"Zempo", "scopus_author_id"=>"26667363900"}, {"first_name"=>"Hisashi", "last_name"=>"Naito", "scopus_author_id"=>"7201588129"}, {"first_name"=>"Yukiko", "last_name"=>"Abe", "scopus_author_id"=>"36149138300"}, {"first_name"=>"Yasumichi", "last_name"=>"Arai", "scopus_author_id"=>"55754938000"}, {"first_name"=>"Haruka", "last_name"=>"Murakami", "scopus_author_id"=>"35620854800"}, {"first_name"=>"Motohiko", "last_name"=>"Miyachi", "scopus_author_id"=>"7005777990"}, {"first_name"=>"Helios", "last_name"=>"Pareja-Galeano", "scopus_author_id"=>"51663826500"}, {"first_name"=>"Enzo", "last_name"=>"Emanuele", "scopus_author_id"=>"6602949682"}, {"first_name"=>"Nobuyoshi", "last_name"=>"Hirose", "scopus_author_id"=>"7103121952"}, {"first_name"=>"Alejandro", "last_name"=>"Lucia", "scopus_author_id"=>"7102180908"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"613255943", "issn"=>"19326203", "isbn"=>"1932-6203 (Electronic)\r1932-6203 (Linking)", "doi"=>"10.1371/journal.pone.0166605", "scopus"=>"2-s2.0-84995906211", "pmid"=>"27861536", "sgr"=>"84995906211"}, "id"=>"25c6172e-b24c-3de9-b134-e6c7eadc51e4", "abstract"=>"Myostatin (MSTN) and alpha-actinin-3 (ACTN3) genes are potentially associated with preservation of muscle mass and oxidative capacity, respectively. To explore the possible role of these genes in exceptional longevity (EL), the allele/genotype frequency distribution of two polymorphisms in MSTN (rs1805086, K153R) and ACTN3 (rs1815739, R577X) was studied in Japanese centenarians of both sexes (n = 742) and healthy controls (n = 814). The rs1805086 R-allele (theoretically associated with muscle mass preservation at the expense of oxidative capacity) was virtually absent in the two groups, where genotype distributions were virtually identical. Likewise, no differences in allele (p = 0.838 (women); p = 0.193 (men); p = 0.587 (both sexes)) or genotype distribution were found between groups for ACTN3 rs1815739 (p = 0.975 (women), p = 0.136 (men), p = 0.752 (both sexes)). Of note, however, the frequency of the rs1805086 R-allele observed here is the lowest been reported to date whereas that of the 'highly oxidative/efficient' rs1815739 XX genotype in Japanese male centenarians (33.3%) or supercentenarians of both sexes (>/=110 years) are the highest (32.6%), for a non-American population. No definite conclusions can be inferred in relation to EL owing to its lack of association with both rs1815739 and rs1805086. However, it cannot be excluded that these gene variants could eventually be related to a \"healthy\" metabolic phenotype in the Japanese population. Further research might determine if such metabolic profile is among the factors that can potentially predispose these individuals to live longer than Caucasians and what genetic variants might be actually involved.", "link"=>"http://www.mendeley.com/research/musclerelated-polymorphisms-mstn-rs1805086-actn3-rs1815739-not-associated-exceptional-longevity-japa", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>4, "Student > Ph. D. Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Engineering"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>1, "Sports and Recreations"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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