High Diversity and Variability in the Vaginal Microbiome in Women following Preterm Premature Rupture of Membranes (PPROM): A Prospective Cohort Study
Publication Date
November 18, 2016
Authors
Teenus Paramel Jayaprakash, Emily C. Wagner, Julie Van Schalkwyk, Arianne Y. K. Albert, et al
Volume
11
Issue
11
Pages
e0166794
DOI
https://dx.plos.org/10.1371/journal.pone.0166794
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0166794
Scopus
84996555046
Mendeley
http://www.mendeley.com/research/high-diversity-variability-vaginal-microbiome-women-following-preterm-premature-rupture-membranes-pp
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Mendeley | Further Information

{"title"=>"High diversity and variability in the vaginal microbiome in women following Preterm Premature Rupture of Membranes (PPROM): A prospective cohort study", "type"=>"journal", "authors"=>[{"first_name"=>"Teenus Paramel", "last_name"=>"Jayaprakash", "scopus_author_id"=>"56316280600"}, {"first_name"=>"Emily C.", "last_name"=>"Wagner", "scopus_author_id"=>"16205709800"}, {"first_name"=>"Julie", "last_name"=>"Van Schalkwyk", "scopus_author_id"=>"57192214267"}, {"first_name"=>"Arianne Y.K.", "last_name"=>"Albert", "scopus_author_id"=>"7202795040"}, {"first_name"=>"Janet E.", "last_name"=>"Hill", "scopus_author_id"=>"7404770905"}, {"first_name"=>"Deborah M.", "last_name"=>"Money", "scopus_author_id"=>"7004281603"}, {"first_name"=>"Sean M.", "last_name"=>"Hemmingsen", "scopus_author_id"=>"7003817448"}, {"first_name"=>"Eliana", "last_name"=>"Castillo", "scopus_author_id"=>"18534147700"}, {"first_name"=>"Patricia A.", "last_name"=>"Janssen", "scopus_author_id"=>"7201762478"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "scopus"=>"2-s2.0-84996555046", "pui"=>"613255996", "doi"=>"10.1371/journal.pone.0166794", "sgr"=>"84996555046", "pmid"=>"27861554"}, "id"=>"f7fe70ab-34a8-3513-843a-15c17c817bb2", "abstract"=>"Objective\r\nTo characterize the vaginal microbiota of women following preterm premature rupture of membranes (PPROM), and determine if microbiome composition predicts latency duration and perinatal outcomes.\r\n\r\nDesign\r\nA prospective cohort study\r\n\r\nSetting\r\nCanada\r\n\r\nPopulation\r\nWomen with PPROM between 24+0 and 33+6 weeks gestational age (GA).\r\n\r\nMethods\r\nMicrobiome profiles, based on pyrosequencing of the cpn60 universal target, were generated from vaginal samples at time of presentation with PPROM, weekly thereafter, and at delivery.\r\n\r\nMain Outcome Measures\r\nVaginal microbiome composition, latency duration, gestational age at delivery, perinatal outcomes.\r\n\r\nResults\r\nMicrobiome profiles were generated from 70 samples from 36 women. Mean GA at PPROM was 28.8 wk (mean latency 2.7 wk). Microbiome profiles were highly diverse but sequences representing Megasphaera type 1 and Prevotella spp. were detected in all vaginal samples. Only 13/70 samples were dominated by Lactobacillus spp. Microbiome profiles at the time of membrane rupture did not cluster by gestational age at PPROM, latency duration, presence of chorioamnionitis or by infant outcomes. Mycoplasma and/or Ureaplasma were detected by PCR in 81% (29/36) of women, and these women had significantly lower GA at delivery and correspondingly lower birth weight infants than Mycoplasma and/or Ureaplasma negative women.\r\n\r\nConclusion\r\nWomen with PPROM had mixed, abnormal vaginal microbiota but the microbiome profile at PPROM did not correlate with latency duration. Prevotella spp. and Megasphaera type I were ubiquitous. The presence of Mollicutes in the vaginal microbiome was associated with lower GA at delivery. The microbiome was remarkably unstable during the latency period.", "link"=>"http://www.mendeley.com/research/high-diversity-variability-vaginal-microbiome-women-following-preterm-premature-rupture-membranes-pp", "reader_count"=>25, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Researcher"=>5, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Biochemistry, Genetics and Molecular Biology"=>4, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>3, "Sports and Recreations"=>1, "Immunology and Microbiology"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Sports and Recreations"=>{"Sports and Recreations"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>3}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>4}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>0}

Scopus | Further Information

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