BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage
Publication Date
December 13, 2016
Authors
Katja Storch, Ellen Dickreuter, Anna Artati, Jerzy Adamski, et al
Volume
11
Issue
12
Pages
e0167931
DOI
https://dx.plos.org/10.1371/journal.pone.0167931
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0167931
Scopus
85005950165
Mendeley
http://www.mendeley.com/research/bemer-electromagnetic-field-therapy-reduces-cancer-cell-radioresistance-enhanced-ros-formation-induc
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Mendeley | Further Information

{"title"=>"BEMER electromagnetic field therapy reduces cancer cell radioresistance by enhanced ROS formation and induced DNA Damage", "type"=>"journal", "authors"=>[{"first_name"=>"Katja", "last_name"=>"Storch", "scopus_author_id"=>"23037055200"}, {"first_name"=>"Ellen", "last_name"=>"Dickreuter", "scopus_author_id"=>"55260142700"}, {"first_name"=>"Anna", "last_name"=>"Artati", "scopus_author_id"=>"55965277700"}, {"first_name"=>"Jerzy", "last_name"=>"Adamski", "scopus_author_id"=>"7004973111"}, {"first_name"=>"Nils", "last_name"=>"Cordes", "scopus_author_id"=>"55898268000"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85005950165", "doi"=>"10.1371/journal.pone.0167931", "pui"=>"613644269", "issn"=>"19326203", "pmid"=>"27959944", "scopus"=>"2-s2.0-85005950165"}, "id"=>"122cc51d-5908-32dd-9579-a87f4cb409ce", "abstract"=>"© 2016 Storch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Each year more than 450,000 Germans are expected to be diagnosed with cancer subsequently receiving standard multimodal therapies including surgery, chemotherapy and radiotherapy. On top, molecular-targeted agents are increasingly administered. Owing to intrinsic and acquired resistance to these therapeutic approaches, both the better molecular understanding of tumor biology and the consideration of alternative and complementary therapeutic support are warranted and open up broader and novel possibilities for therapy personalization. Particularly the latter is underpinned by the increasing utilization of noninvasive complementary and alternative medicine by the population. One investigated approach is the application of low-dose electromagnetic fields (EMF) to modulate cellular processes. A particular system is the BEMER therapy as a Physical Vascular Therapy for which a normalization of the microcirculation has been demonstrated by a low-frequency, pulsed EMF pattern. Open remains whether this EMF pattern impacts on cancer cell survival upon treatment with radiotherapy, chemotherapy and the molecular-targeted agent Cetuximab inhibiting the epidermal growth factor receptor. Using more physiological, three-dimensional, matrix-based cell culture models and cancer cell lines originating from lung, head and neck, colorectal and pancreas, we show significant changes in distinct intermediates of the glycolysis and tricarboxylic acid cycle pathways and enhanced cancer cell radio-sensitization associated with increased DNA double strand break numbers and higher levels of reactive oxygen species upon BEMER treatment relative to controls. Intriguingly, exposure of cells to the BEMER EMF pattern failed to result in sensitization to chemotherapy and Cetuximab. Further studies are necessary to better understand the mechanisms underlying the cellular alterations induced by the BEMER EMF pattern and to clarify the application areas for human disease.", "link"=>"http://www.mendeley.com/research/bemer-electromagnetic-field-therapy-reduces-cancer-cell-radioresistance-enhanced-ros-formation-induc", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Master"=>1, "Other"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Master"=>1, "Other"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>3}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "reader_count_by_country"=>{"Germany"=>1}, "group_count"=>0}

Scopus | Further Information

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