Application of Bacteriophage-containing Aerosol against Nosocomial Transmission of Carbapenem-Resistant Acinetobacter baumannii in an Intensive Care Unit
Publication Date
December 16, 2016
Authors
Yu Huai Ho, Chun Chieh Tseng, Lih Shinn Wang, Yi Ting Chen, et al
Volume
11
Issue
12
Pages
e0168380
DOI
https://dx.plos.org/10.1371/journal.pone.0168380
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0168380
Scopus
85006700632
Mendeley
http://www.mendeley.com/research/application-bacteriophagecontaining-aerosol-against-nosocomial-transmission-carbapenemresistant-acin-1
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Mendeley | Further Information

{"title"=>"Application of bacteriophage-containing aerosol against nosocomial transmission of carbapenem-resistant acinetobacter baumannii in an intensive care unit", "type"=>"journal", "authors"=>[{"first_name"=>"Yu Huai", "last_name"=>"Ho", "scopus_author_id"=>"8410763400"}, {"first_name"=>"Chun Chieh", "last_name"=>"Tseng", "scopus_author_id"=>"54407539100"}, {"first_name"=>"Lih Shinn", "last_name"=>"Wang", "scopus_author_id"=>"8410763100"}, {"first_name"=>"Yi Ting", "last_name"=>"Chen", "scopus_author_id"=>"35081735200"}, {"first_name"=>"Guan Jin", "last_name"=>"Ho", "scopus_author_id"=>"57192544615"}, {"first_name"=>"Teng Yi", "last_name"=>"Lin", "scopus_author_id"=>"14045207800"}, {"first_name"=>"Ling Yi", "last_name"=>"Wang", "scopus_author_id"=>"57192557406"}, {"first_name"=>"Li Kuang", "last_name"=>"Chen", "scopus_author_id"=>"57137125300"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85006700632", "sgr"=>"85006700632", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0168380", "pmid"=>"27992494", "isbn"=>"1932-6203", "pui"=>"613725856"}, "id"=>"a62d975a-d01c-3bbb-9cf1-ca88e375eef3", "abstract"=>"Background Carbapenem-resistant Acinetobacter baumannii (CRAB) is associated with nosocomial infections worldwide. Here, we used phage as a potential agent to evaluate the efficacy of daily cleaning practices combined with a bacteriophage-containing aerosol against CRAB. Methods A two-phase prospective intervention study was performed at a 945-bed public teaching hospital. From March to December 2013, we performed terminal cleaning using standard procedures plus an aerosol with active bacteriophage in the intensive care units to evaluate the impact on nosocomial incidence density, carbapenem-resistance rates and antimicrobial drug consumption amounts. Patients with culture proven CRAB infection were transferred to the isolation room when the phage aerosol cleaning had been completed. Results A total of 264 new acquisitions of CRAB were identified in the intensive care units (191 in the pre-intervention period and 73 in the intervention period). The rates of new acquisitions of CRAB in the intensive care units decreased from 8.57 per 1000 patient-days in the pre-intervention period to 5.11 per 1000 patient-days in the intervention period (p = 0.0029). The mean percentage of resistant isolates CRAB decreased from 87.76% to 46.07% in the intensive care units (p = 0.001). All of the antimicrobials showed a significant reduction in consumption except imipenem. Conclusions The bacteriophage was successful in decreasing the rates of infection caused by CRAB across intensive care units in a large teaching hospital.", "link"=>"http://www.mendeley.com/research/application-bacteriophagecontaining-aerosol-against-nosocomial-transmission-carbapenemresistant-acin-1", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>3, "Other"=>2, "Student > Master"=>5, "Student > Bachelor"=>1, "Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Nursing and Health Professions"=>4, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>5, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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