Mendeley | Further Information

{"title"=>"Use of proton pump inhibitors and the risk of hospitalization for infectious gastroenteritis", "type"=>"journal", "authors"=>[{"first_name"=>"Yingxi", "last_name"=>"Chen", "scopus_author_id"=>"56181012000"}, {"first_name"=>"Bette", "last_name"=>"Liu", "scopus_author_id"=>"57189615335"}, {"first_name"=>"Kathryn", "last_name"=>"Glass", "scopus_author_id"=>"12766216900"}, {"first_name"=>"Wei", "last_name"=>"Du", "scopus_author_id"=>"57198397745"}, {"first_name"=>"Emily", "last_name"=>"Banks", "scopus_author_id"=>"7004711004"}, {"first_name"=>"Martyn", "last_name"=>"Kirk", "scopus_author_id"=>"7202651670"}], "year"=>2016, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pmid"=>"27997598", "scopus"=>"2-s2.0-85006921227", "doi"=>"10.1371/journal.pone.0168618", "pui"=>"613783575", "isbn"=>"1111111111", "sgr"=>"85006921227"}, "id"=>"dc002eb3-7d39-3403-8e26-e00e6cbd7875", "abstract"=>"INTRODUCTION To quantify the association between PPI use, type and dose and infectious gastroenteritis hospitalization in a population-based cohort of middle-aged and older adults. METHODS Prospective study of 38,019 concession card holders followed up over 6 years in the Sax Institute's 45 and Up Study. Data from the baseline questionnaire were linked to prescription medication, hospitalization, notifiable disease, cancer registry and death datasets from 2006-2012. Associations between PPI use and gastroenteritis hospitalization were examined using Cox regressions with age as the underlying time variable. RESULTS Among 38,019 participants, the median age was 69.7 years, and 57.3% were women. Compared to non-users, current PPI users were more likely to be older, and have a higher BMI. During follow-up there were 1,982 incident gastroenteritis hospitalizations (crude rate: 12.9 per 1000 person-years, 95% CI: 12.3-13.5). PPI use was significantly associated with infectious gastroenteritis hospitalization (aHR 1.4, 95% CI: 1.2-1.5). Among current users, a dose-response relationship was observed between the average daily dose (DDD) dispensed per day and infectious gastroenteritis hospitalization (Ptrend<0.001). We also observed higher rates of infectious gastroenteritis hospitalization and greater PPI use among participants with a history of chronic bowel problems (aHR 2.2, 95% CI: 1.9-2.5). There was no difference in risk by type of PPI. Recent use of H2 receptors was not associated with gastroenteritis hospitalization. CONCLUSION PPI use is associated with an increased risk of infectious gastroenteritis hospitalization. Clinicians should be aware of this risk when considering PPI therapy.", "link"=>"http://www.mendeley.com/research/proton-pump-inhibitors-risk-hospitalization-infectious-gastroenteritis", "reader_count"=>12, "reader_count_by_academic_status"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Professor > Associate Professor"=>1, "Researcher"=>2, "Student > Doctoral Student"=>2, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>2, "Student > Bachelor"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>7, "Agricultural and Biological Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>7}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "reader_count_by_country"=>{"Australia"=>1}, "group_count"=>1}

CrossRef

• http://doi.org/10.1111/liv.14012
• http://doi.org/10.1016/j.jvoice.2020.01.018
• http://doi.org/10.1007/s40266-018-0537-3
• http://doi.org/10.1080/17425255.2018.1461835
• http://doi.org/10.12968/jokc.2018.3.1.6
• http://doi.org/10.1007/s40266-019-00704-6
• http://doi.org/10.1371/journal.pone.0193411
• http://doi.org/10.1093/cid/ciy1142
• http://doi.org/10.1002/aid2.13164
• http://doi.org/10.1089/mdr.2020.0017
• http://doi.org/10.12968/gasn.2017.15.2.12

Scopus | Further Information

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• {"id"=>"819394743599669248", "text"=>"Increased risk of?Campylobacter,?Salmonella?and?C.?difficile?infection if you take a protein pump inhibitor (PPI) ?https://t.co/rcZ1kYSMsA", "created_at"=>"2017-01-12T04:05:05Z", "user"=>"CollignonPeter", "user_name"=>"Peter Collignon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000045776734/9fa32e52a865bd67e299eb519a23c34f_normal.jpeg"}
• {"id"=>"819395490357706752", "text"=>"Acid in your stomach part of our natural barriers against infection. If you turn off the acid then more infections. https://t.co/rcZ1kYSMsA", "created_at"=>"2017-01-12T04:08:03Z", "user"=>"CollignonPeter", "user_name"=>"Peter Collignon", "user_profile_image"=>"http://pbs.twimg.com/profile_images/378800000045776734/9fa32e52a865bd67e299eb519a23c34f_normal.jpeg"}
• {"id"=>"819438462763839493", "text"=>"PPI use is associated with an increased risk of infectious gastroenteritis hospitalisation - #FOAMED https://t.co/sZuIx4uhDM", "created_at"=>"2017-01-12T06:58:48Z", "user"=>"poped01", "user_name"=>"David Pope", "user_profile_image"=>"http://pbs.twimg.com/profile_images/472053760575811585/Vo5SQWkD_normal.jpeg"}
• {"id"=>"820984039725088768", "text"=>"Proton Pump Inhibitors (PPIs) have been around for a very long time. but research still goes on into their use.... https://t.co/BLxY31QQbN", "created_at"=>"2017-01-16T13:20:22Z", "user"=>"BiteTheDust", "user_name"=>"Robbo", "user_profile_image"=>"http://pbs.twimg.com/profile_images/421471112/BteTheDust_normal.jpg"}

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• {"unique-ip"=>"40", "full-text"=>"49", "pdf"=>"2", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"0", "year"=>"2020", "month"=>"6"}
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• {"unique-ip"=>"68", "full-text"=>"89", "pdf"=>"5", "scanned-summary"=>"0", "scanned-page-browse"=>"0", "figure"=>"0", "supp-data"=>"0", "cited-by"=>"1", "year"=>"2020", "month"=>"8"}
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F1000Prime