Metabolomic Profiling in Individuals with a Failing Kidney Allograft
Publication Date
January 04, 2017
Authors
Roberto Bassi, Monika A. Niewczas, Luigi Biancone, Stefania Bussolino, et al
Volume
12
Issue
1
Pages
e0169077
DOI
https://dx.plos.org/10.1371/journal.pone.0169077
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0169077
Scopus
85008329954
Mendeley
http://www.mendeley.com/research/metabolomic-profiling-individuals-failing-kidney-allograft
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Mendeley | Further Information

{"title"=>"Metabolomic profiling in individuals with a failing kidney allograft", "type"=>"journal", "authors"=>[{"first_name"=>"Roberto", "last_name"=>"Bassi", "scopus_author_id"=>"55148604900"}, {"first_name"=>"Monika A.", "last_name"=>"Niewczas", "scopus_author_id"=>"7003753113"}, {"first_name"=>"Luigi", "last_name"=>"Biancone", "scopus_author_id"=>"7004535812"}, {"first_name"=>"Stefania", "last_name"=>"Bussolino", "scopus_author_id"=>"6603165133"}, {"first_name"=>"Sai", "last_name"=>"Merugumala", "scopus_author_id"=>"55241663700"}, {"first_name"=>"Sara", "last_name"=>"Tezza", "scopus_author_id"=>"54782051400"}, {"first_name"=>"Francesca", "last_name"=>"D'Addio", "scopus_author_id"=>"35619657700"}, {"first_name"=>"Moufida Ben", "last_name"=>"Nasr", "scopus_author_id"=>"56136434200"}, {"first_name"=>"Alessandro", "last_name"=>"Valderrama-Vasquez", "scopus_author_id"=>"55982491400"}, {"first_name"=>"Vera", "last_name"=>"Usuelli", "scopus_author_id"=>"19934317900"}, {"first_name"=>"Valentina", "last_name"=>"De Zan", "scopus_author_id"=>"57192836525"}, {"first_name"=>"Basset", "last_name"=>"El Essawy", "scopus_author_id"=>"14049667100"}, {"first_name"=>"Massimo", "last_name"=>"Venturini", "scopus_author_id"=>"57190078195"}, {"first_name"=>"Antonio", "last_name"=>"Secchi", "scopus_author_id"=>"55147568100"}, {"first_name"=>"Francesco", "last_name"=>"De Cobelli", "scopus_author_id"=>"7003492338"}, {"first_name"=>"Alexander", "last_name"=>"Lin", "scopus_author_id"=>"7402061836"}, {"first_name"=>"Anil", "last_name"=>"Chandraker", "scopus_author_id"=>"14025499200"}, {"first_name"=>"Paolo", "last_name"=>"Fiorina", "scopus_author_id"=>"7004237874"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85008329954", "sgr"=>"85008329954", "doi"=>"10.1371/journal.pone.0169077", "pui"=>"613964394", "pmid"=>"28052095", "isbn"=>"1111111111", "issn"=>"19326203"}, "id"=>"0a4aaf38-ef8e-367a-b419-d5f9b7fdd3b2", "abstract"=>"BACKGROUND Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. METHODS To explore metabolomic abnormalities in individuals with a failing kidney allograft, we analyzed by liquid chromatography-mass spectrometry (LC-MS/MS; for ex vivo profiling of serum and urine) and two dimensional correlated spectroscopy (2D COSY; for in vivo study of the kidney graft) 40 subjects with varying degrees of chronic allograft dysfunction stratified by tertiles of glomerular filtration rate (GFR; T1, T2, T3). Ten healthy non-allograft individuals were chosen as controls. RESULTS LC-MS/MS analysis revealed a dose-response association between GFR and serum concentration of tryptophan, glutamine, dimethylarginine isomers (asymmetric [A]DMA and symmetric [S]DMA) and short-chain acylcarnitines (C4 and C12), (test for trend: T1-T3 = p<0.05; p = 0.01; p<0.001; p = 0.01; p = 0.01; p<0.05, respectively). The same association was found between GFR and urinary levels of histidine, DOPA, dopamine, carnosine, SDMA and ADMA (test for trend: T1-T3 = p<0.05; p<0.01; p = 0.001; p<0.05; p = 0.001; p<0.001; p<0.01, respectively). In vivo 2D COSY of the kidney allograft revealed significant reduction in the parenchymal content of choline, creatine, taurine and threonine (all: p<0.05) in individuals with lower GFR levels. CONCLUSIONS We report an association between renal function and altered metabolomic profile in renal transplant individuals with different degrees of kidney graft function.", "link"=>"http://www.mendeley.com/research/metabolomic-profiling-individuals-failing-kidney-allograft", "reader_count"=>21, "reader_count_by_academic_status"=>{"Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Researcher"=>6, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Student > Master"=>4, "Other"=>4, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>8, "Agricultural and Biological Sciences"=>4, "Veterinary Science and Veterinary Medicine"=>1, "Chemistry"=>2, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>8}, "Chemistry"=>{"Chemistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>4}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>1}}, "group_count"=>0}

Scopus | Further Information

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