Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology
Publication Date
January 19, 2017
Authors
Oliver Eidel, Sina Burth, Jan Oliver Neumann, Pascal J. Kieslich, et al
Volume
12
Issue
1
Pages
e0169292
DOI
https://dx.plos.org/10.1371/journal.pone.0169292
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0169292
Scopus
85010064592
Mendeley
http://www.mendeley.com/research/tumor-infiltration-enhancing-nonenhancing-parts-glioblastoma-correlation-histopathology
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Mendeley | Further Information

{"title"=>"Tumor infiltration in enhancing and non-enhancing parts of glioblastoma: A correlation with histopathology", "type"=>"journal", "authors"=>[{"first_name"=>"Oliver", "last_name"=>"Eidel", "scopus_author_id"=>"56433705100"}, {"first_name"=>"Sina", "last_name"=>"Burth", "scopus_author_id"=>"56433380100"}, {"first_name"=>"Jan Oliver", "last_name"=>"Neumann", "scopus_author_id"=>"7202752795"}, {"first_name"=>"Pascal J.", "last_name"=>"Kieslich", "scopus_author_id"=>"56433468600"}, {"first_name"=>"Felix", "last_name"=>"Sahm", "scopus_author_id"=>"36446567000"}, {"first_name"=>"Christine", "last_name"=>"Jungk", "scopus_author_id"=>"56008884500"}, {"first_name"=>"Philipp", "last_name"=>"Kickingereder", "scopus_author_id"=>"37072704100"}, {"first_name"=>"Sebastian", "last_name"=>"Bickelhaupt", "scopus_author_id"=>"55279357200"}, {"first_name"=>"Sibu", "last_name"=>"Mundiyanapurath", "scopus_author_id"=>"25947684700"}, {"first_name"=>"Philipp", "last_name"=>"B�umer", "scopus_author_id"=>"57201164693"}, {"first_name"=>"Wolfgang", "last_name"=>"Wick", "scopus_author_id"=>"7003287906"}, {"first_name"=>"Heinz Peter", "last_name"=>"Schlemmer", "scopus_author_id"=>"7003821622"}, {"first_name"=>"Karl", "last_name"=>"Kiening", "scopus_author_id"=>"7004215031"}, {"first_name"=>"Andreas", "last_name"=>"Unterberg", "scopus_author_id"=>"7004554335"}, {"first_name"=>"Martin", "last_name"=>"Bendszus", "scopus_author_id"=>"7006493496"}, {"first_name"=>"Alexander", "last_name"=>"Radbruch", "scopus_author_id"=>"36350332600"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85010064592", "sgr"=>"85010064592", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0169292", "pmid"=>"28103256", "isbn"=>"1111111111", "pui"=>"614139268"}, "id"=>"d9e834b2-9511-30b6-9489-c8d6bf538b7c", "abstract"=>"PURPOSE To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on contrast enhanced T1-weighted MRI scans (cT1). MATERIALS AND METHODS In 37 patients with newly diagnosed glioblastoma who underwent stereotactic biopsy, we obtained a correlation of 561 1mm3 biopsy specimens with their corresponding position on the intraoperative cT1 image at 1.5 Tesla. Biopsy points were categorized as enhancing (CE), non-enhancing (NE) or necrotic (NEC) on cT1 and tissue samples were categorized as \"viable tumor cells\", \"blood\" or \"necrotic tissue (with or without cellular component)\". Cell counting was done semi-automatically. RESULTS NE had the highest content of tissue categorized as viable tumor cells (89% vs. 60% in CE and 30% NEC, respectively). Besides, the average cell density for NE (3764 ± 2893 cells/mm2) was comparable to CE (3506 ± 3116 cells/mm2), while NEC had a lower cell density with 2713 ± 3239 cells/mm2. If necrotic parts and bleeds were excluded, cell density in biopsies categorized as \"viable tumor tissue\" decreased from the center of the tumor (NEC, 5804 ± 3480 cells/mm2) to CE (4495 ± 3209 cells/mm2) and NE (4130 ± 2817 cells/mm2). DISCUSSION The appearance of a glioblastoma on a cT1 image (circular enhancement, central necrosis, peritumoral edema) does not correspond to its diffuse histopathological composition. Cell density is elevated in both CE and NE parts. Hence, our study suggests that NE contains considerable amounts of infiltrative tumor with a high cellularity which might be considered in resection planning.", "link"=>"http://www.mendeley.com/research/tumor-infiltration-enhancing-nonenhancing-parts-glioblastoma-correlation-histopathology", "reader_count"=>19, "reader_count_by_academic_status"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>4, "Professor > Associate Professor"=>1, "Researcher"=>3, "Student > Doctoral Student"=>3, "Student > Ph. D. Student"=>4, "Student > Postgraduate"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>4, "Engineering"=>1, "Medicine and Dentistry"=>10, "Agricultural and Biological Sciences"=>2, "Neuroscience"=>1, "Physics and Astronomy"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>10}, "Neuroscience"=>{"Neuroscience"=>1}, "Physics and Astronomy"=>{"Physics and Astronomy"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>4}}, "group_count"=>2}

Scopus | Further Information

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