Clinical Significance of Two Real-Time PCR Assays for Chronic Hepatitis C Patients Receiving Protease Inhibitor-Based Therapy
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{"title"=>"Clinical significance of two real-time PCR assays for chronic hepatitis C patients receiving protease inhibitor-based therapy", "type"=>"journal", "authors"=>[{"first_name"=>"Takako", "last_name"=>"Inoue", "scopus_author_id"=>"16477189500"}, {"first_name"=>"Su Su", "last_name"=>"Hmwe", "scopus_author_id"=>"20734174500"}, {"first_name"=>"Noritomo", "last_name"=>"Shimada", "scopus_author_id"=>"7202989720"}, {"first_name"=>"Keizo", "last_name"=>"Kato", "scopus_author_id"=>"55256886700"}, {"first_name"=>"Tatsuya", "last_name"=>"Ide", "scopus_author_id"=>"7202660065"}, {"first_name"=>"Takuji", "last_name"=>"Torimura", "scopus_author_id"=>"7004343565"}, {"first_name"=>"Takashi", "last_name"=>"Kumada", "scopus_author_id"=>"21640576300"}, {"first_name"=>"Hidenori", "last_name"=>"Toyoda", "scopus_author_id"=>"7202067754"}, {"first_name"=>"Akihito", "last_name"=>"Tsubota", "scopus_author_id"=>"55802135400"}, {"first_name"=>"Koichi", "last_name"=>"Takaguchi", "scopus_author_id"=>"6602515765"}, {"first_name"=>"Takaji", "last_name"=>"Wakita", "scopus_author_id"=>"7005812729"}, {"first_name"=>"Yasuhito", "last_name"=>"Tanaka", "scopus_author_id"=>"7405315865"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85010822294", "pmid"=>"28118381", "pui"=>"614178733", "scopus"=>"2-s2.0-85010822294", "doi"=>"10.1371/journal.pone.0170667", "issn"=>"19326203"}, "id"=>"448639dc-287f-3387-b400-13223733d906", "abstract"=>"The aim of this study was to determine the efficacy of two hepatitis C virus (HCV) real-time PCR assays, the COBAS AmpliPrep/COBAS TaqMan HCV test (CAP/CTM) and the Abbott RealTime HCV test (ART), for predicting the clinical outcomes of patients infected with HCV who received telaprevir (TVR)-based triple therapy or daclatasvir/asunaprevir (DCV/ASV) dual therapy. The rapid virological response rates in patients receiving TVR-based triple therapy were 92% (23/25) and 40% (10/25) for CAP/CTM and ART, respectively. The false omission rate (FOR) of ART was 93.3% (14/15), indicating that CAP/CTM could accurately predict clinical outcome in the early phase. In an independent examination of 20 patients receiving TVR-based triple therapy who developed viral breakthrough or relapse, the times to HCV disappearance by ART were longer than by CAP/CTM, whereas the times to HCV reappearance were similar. In an independent experiment of WHO standard HCV RNA serially diluted in serum containing TVR, the analytical sensitivities of CAP/CTM and ART were similar. However, cell cultures transfected with HCV and grown in medium containing TVR demonstrated that ART detected HCV RNA for a longer time than CAP/CTM. Similar results were found for 42 patients receiving DCV/ASV dual therapy. The FOR of ART was 73.3% (11/15) at week 8 after initiation of therapy, indicating that ART at week 8 could not accurately predict the clinical outcome. In conclusion, although CAP/CTM and ART detected HCV RNA with comparable analytical sensitivity, CAP/CTM might be preferable for predicting the clinical outcomes of patients receiving protease inhibitor-based therapy.", "link"=>"http://www.mendeley.com/research/clinical-significance-two-realtime-pcr-assays-chronic-hepatitis-c-patients-receiving-protease-inhibi", "reader_count"=>3, "reader_count_by_academic_status"=>{"Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_user_role"=>{"Student > Ph. D. Student"=>1, "Student > Bachelor"=>1, "Professor > Associate Professor"=>1}, "reader_count_by_subject_area"=>{"Agricultural and Biological Sciences"=>1, "Immunology and Microbiology"=>1, "Mathematics"=>1}, "reader_count_by_subdiscipline"=>{"Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Mathematics"=>{"Mathematics"=>1}}, "group_count"=>0}

Scopus | Further Information

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