Repositioning approved drugs for the treatment of problematic cancers using a screening approach
Publication Date
February 06, 2017
Authors
Hristo P. Varbanov, Fabien Kuttler, Damiano Banfi, Gerardo Turcatti, et al
Volume
12
Issue
2
Pages
e0171052
DOI
https://dx.plos.org/10.1371/journal.pone.0171052
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171052
Scopus
85011661914
Mendeley
http://www.mendeley.com/research/repositioning-approved-drugs-treatment-problematic-cancers-using-screening-approach
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Mendeley | Further Information

{"title"=>"Repositioning approved drugs for the treatment of problematic cancers using a screening approach", "type"=>"journal", "authors"=>[{"first_name"=>"Hristo P.", "last_name"=>"Varbanov", "scopus_author_id"=>"24537933300"}, {"first_name"=>"Fabien", "last_name"=>"Kuttler", "scopus_author_id"=>"8627551100"}, {"first_name"=>"Damiano", "last_name"=>"Banfi", "scopus_author_id"=>"6602194594"}, {"first_name"=>"Gerardo", "last_name"=>"Turcatti", "scopus_author_id"=>"6603641458"}, {"first_name"=>"Paul J.", "last_name"=>"Dyson", "scopus_author_id"=>"56737381800"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85011661914", "sgr"=>"85011661914", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0171052", "pmid"=>"28166232", "isbn"=>"1111111111", "pui"=>"614301365"}, "id"=>"fb4f9240-2e85-3bce-9375-58f400d66c96", "abstract"=>"Advances in treatment strategies together with an earlier diagnosis have considerably increased the average survival of cancer patients over the last four decades. Nevertheless, despite the growing number of new antineoplastic agents introduced each year, there is still no adequate therapy for problematic malignancies such as pancreatic, lung and stomach cancers. Consequently, it is important to ensure that existing drugs used to treat other types of cancers, and potentially other diseases, are not overlooked when searching for new chemotherapy regimens for these problematic cancer types. We describe a screening approach that identifies chemotherapeutics for the treatment of lung and pancreatic cancers, based on drugs already approved for other applications. Initially, the 1280 chemically and pharmacologically diverse compounds from the Prestwick Chemical Library® (PCL) were screened against A549 (lung cancer) and PANC-1 (pancreatic carcinoma) cells using the PrestoBlue fluorescent-based cell viability assay. More than 100 compounds from the PCL were identified as hits in one or both cell lines (80 of them, being drugs used to treat diseases other than cancer). Selected PCL hits were further evaluated in a dose-response manner. Promising candidates for repositioning emanating from this study include antiparasitics, cardiac glycosides, as well as the anticancer drugs vorinostat and topotecan.", "link"=>"http://www.mendeley.com/research/repositioning-approved-drugs-treatment-problematic-cancers-using-screening-approach", "reader_count"=>14, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>2, "Researcher"=>6, "Student > Ph. D. Student"=>3, "Other"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Biochemistry, Genetics and Molecular Biology"=>5, "Agricultural and Biological Sciences"=>3, "Medicine and Dentistry"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Unspecified"=>{"Unspecified"=>1}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>6}

Scopus | Further Information

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