Zika Virus Tissue and Blood Compartmentalization in Acute Infection of Rhesus Macaques
Publication Date
January 31, 2017
Authors
Lark L. Coffey, Patricia A. Pesavento, Rebekah I. Keesler, Anil Singapuri, et al
Volume
12
Issue
1
Pages
e0171148
DOI
https://dx.plos.org/10.1371/journal.pone.0171148
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171148
Scopus
85011309158
Mendeley
http://www.mendeley.com/research/zika-virus-tissue-blood-compartmentalization-acute-infection-rhesus-macaques
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{"title"=>"Zika virus tissue and blood compartmentalization in acute infection of rhesus macaques", "type"=>"journal", "authors"=>[{"first_name"=>"Lark L.", "last_name"=>"Coffey", "scopus_author_id"=>"7003682850"}, {"first_name"=>"Patricia A.", "last_name"=>"Pesavento", "scopus_author_id"=>"6603423764"}, {"first_name"=>"Rebekah I.", "last_name"=>"Keesler", "scopus_author_id"=>"57200427587"}, {"first_name"=>"Anil", "last_name"=>"Singapuri", "scopus_author_id"=>"15520167400"}, {"first_name"=>"Jennifer", "last_name"=>"Watanabe", "scopus_author_id"=>"57193155989"}, {"first_name"=>"Rie", "last_name"=>"Watanabe", "scopus_author_id"=>"57193160458"}, {"first_name"=>"Jo Ann", "last_name"=>"Yee", "scopus_author_id"=>"7203044525"}, {"first_name"=>"Eliza", "last_name"=>"Bliss-Moreau", "scopus_author_id"=>"6506839563"}, {"first_name"=>"Christina", "last_name"=>"Cruzen", "scopus_author_id"=>"27367722600"}, {"first_name"=>"Kari L.", "last_name"=>"Christe", "scopus_author_id"=>"7005714984"}, {"first_name"=>"J. Rachel", "last_name"=>"Reader", "scopus_author_id"=>"7005839091"}, {"first_name"=>"Wilhelm", "last_name"=>"Von Morgenland", "scopus_author_id"=>"8742080100"}, {"first_name"=>"Anne M.", "last_name"=>"Gibbons", "scopus_author_id"=>"57193158743"}, {"first_name"=>"A. Mark", "last_name"=>"Allen", "scopus_author_id"=>"56623864700"}, {"first_name"=>"Jeff", "last_name"=>"Linnen", "scopus_author_id"=>"6603645479"}, {"first_name"=>"Kui", "last_name"=>"Gao", "scopus_author_id"=>"54395231400"}, {"first_name"=>"Eric", "last_name"=>"Delwart", "scopus_author_id"=>"7003328241"}, {"first_name"=>"Graham", "last_name"=>"Simmons", "scopus_author_id"=>"7103069709"}, {"first_name"=>"Mars", "last_name"=>"Stone", "scopus_author_id"=>"55417671000"}, {"first_name"=>"Marion", "last_name"=>"Lanteri", "scopus_author_id"=>"6701595069"}, {"first_name"=>"Sonia", "last_name"=>"Bakkour", "scopus_author_id"=>"6507121597"}, {"first_name"=>"Michael", "last_name"=>"Busch", "scopus_author_id"=>"26641634900"}, {"first_name"=>"John", "last_name"=>"Morrison", "scopus_author_id"=>"57136016000"}, {"first_name"=>"Koen K.A.", "last_name"=>"Van Rompay", "scopus_author_id"=>"7004357217"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85011309158", "pmid"=>"28141843", "pui"=>"614240311", "issn"=>"19326203", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85011309158", "doi"=>"10.1371/journal.pone.0171148"}, "id"=>"c094fe2b-bf8c-39f9-b3a4-ad0d2df40a93", "abstract"=>"Animal models of Zika virus (ZIKV) are needed to better understand tropism and pathogenesis and to test candidate vaccines and therapies to curtail the pandemic. Humans and rhesus macaques possess similar fetal development and placental biology that is not shared between humans and rodents. We inoculated 2 non-pregnant rhesus macaques with a 2015 Brazilian ZIKV strain. Consistent with most human infections, the animals experienced no clinical disease but developed short-lived plasma viremias that cleared as neutralizing antibody developed. In 1 animal, viral RNA (vRNA) could be detected longer in whole blood than in plasma. Despite no major histopathologic changes, many adult tissues contained vRNA 14 days post-infection with highest levels in hemolymphatic tissues. These observations warrant further studies to investigate ZIKV persistence and its potential clinical implications for transmission via blood products or tissue and organ transplants.", "link"=>"http://www.mendeley.com/research/zika-virus-tissue-blood-compartmentalization-acute-infection-rhesus-macaques", "reader_count"=>42, "reader_count_by_academic_status"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>3, "Professor > Associate Professor"=>1, "Librarian"=>1, "Researcher"=>10, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>6, "Student > Postgraduate"=>1, "Student > Master"=>6, "Other"=>2, "Student > Bachelor"=>6, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>5, "Nursing and Health Professions"=>1, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>9, "Medicine and Dentistry"=>11, "Neuroscience"=>3, "Veterinary Science and Veterinary Medicine"=>2, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Psychology"=>1, "Social Sciences"=>2, "Immunology and Microbiology"=>4}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>11}, "Neuroscience"=>{"Neuroscience"=>3}, "Social Sciences"=>{"Social Sciences"=>2}, "Psychology"=>{"Psychology"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>4}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>9}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>5}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}, "Veterinary Science and Veterinary Medicine"=>{"Veterinary Science and Veterinary Medicine"=>2}}, "reader_count_by_country"=>{"Brazil"=>1, "France"=>1, "Spain"=>1}, "group_count"=>4}

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Scopus | Further Information

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