Correction: Inflammation Promotes Expression of Stemness-Related Properties in HBV-Related Hepatocellular Carcinoma
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{"title"=>"Correction: Inflammation promotes expression of stemness-related properties in hbv-related hepatocellular carcinoma (PLoS ONE (2016)11:2 (e0149897) DOI: 10.1371/journal.pone.0149897)", "type"=>"generic", "authors"=>[{"first_name"=>"Te Sheng", "last_name"=>"Chang", "scopus_author_id"=>"35763615500"}, {"first_name"=>"Chi Long", "last_name"=>"Chen", "scopus_author_id"=>"7501965241"}, {"first_name"=>"Yu Chih", "last_name"=>"Wu", "scopus_author_id"=>"22837046200"}, {"first_name"=>"Jun Jen", "last_name"=>"Liu", "scopus_author_id"=>"35206266600"}, {"first_name"=>"Yung Che", "last_name"=>"Kuo", "scopus_author_id"=>"36632315400"}, {"first_name"=>"Kam Fai", "last_name"=>"Lee", "scopus_author_id"=>"7501502279"}, {"first_name"=>"Sin Yi", "last_name"=>"Lin", "scopus_author_id"=>"57161254000"}, {"first_name"=>"Sey En", "last_name"=>"Lin", "scopus_author_id"=>"7407158355"}, {"first_name"=>"Shui Yi", "last_name"=>"Tung", "scopus_author_id"=>"7102858905"}, {"first_name"=>"Liang Mou", "last_name"=>"Kuo", "scopus_author_id"=>"12788250600"}, {"first_name"=>"Ying Huang", "last_name"=>"Tsai", "scopus_author_id"=>"7402627938"}, {"first_name"=>"Yen Hua", "last_name"=>"Huang", "scopus_author_id"=>"57154840200"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85010754821", "scopus"=>"2-s2.0-85010754821", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0171176", "pmid"=>"26919045", "pui"=>"614218547"}, "id"=>"878b248c-5e7e-33af-87d6-51d4257ecb2f", "abstract"=>"The expression of cancer stemness is believed to reduce the efficacy of current therapies against hepatocellular carcinoma (HCC). Understanding of the stemness-regulating signaling pathways incurred by a specific etiology can facilitate the development of novel targets for individualized therapy against HCC. Niche environments, such as virus-induced inflammation, may play a crucial role. However, the mechanisms linking inflammation and stemness expression in HCC remain unclear. Here we demonstrated the distinct role of inflammatory mediators in expressions of stemness-related properties involving the pluripotent octamer-binding transcription factor 4 (OCT4) in cell migration and drug resistance of hepatitis B virus-related HCC (HBV-HCC). We observed positive immunorecognition for macrophage chemoattractant protein 1 (MCP-1)/CD68 and OCT4/NANOG in HBV-HCC tissues. The inflammation-conditioned medium (inflamed-CM) generated by lipopolysaccharide-stimulated U937 human leukemia cells significantly increased the mRNA and protein levels of OCT4/NANOG preferentially in HBV-active (HBV+HBsAg+) HCC cells. The inflamed-CM also increased the side population (SP) cell percentage, green fluorescent protein (GFP)-positive cell population, and luciferase activity of OCT4 promoter-GFP/luciferase in HBV-active HCC cells. Furthermore, the inflamed-CM upregulated the expressions of insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) and activated IGF-IR/Akt signaling in HBV-HCC. The IGF-IR phosphorylation inhibitor picropodophyllin (PPP) suppressed inflamed-CM-induced OCT4 and NANOG levels in HBV+HBsAg+ Hep3B cells. Forced expression of OCT4 significantly increased the secondary sphere formation and cell migration, and reduced susceptibility of HBV-HCC cells to cisplatin, bleomycin, and doxorubicin. Taking together, our results show that niche inflammatory mediators play critical roles in inducing the expression of stemness-related properties involving IGF-IR activation, and the upregulation of OCT4 contributes to cancer migration and drug resistance of HBV-HCC cells. Findings in this paper would provide potential targets for a therapeutic strategy targeting on inflammatory environment for HBV-HCC.", "link"=>"http://www.mendeley.com/research/correction-inflammation-promotes-expression-stemnessrelated-properties-hbvrelated-hepatocellular-car", "reader_count"=>8, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>2, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Psychology"=>{"Psychology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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