IgE sensitization to inhalant allergens and the risk of airway infection and disease: A population-based study
Publication Date
February 09, 2017
Authors
Tea Skaaby, Lise Lotte Nystrup Husemoen, Betina Heinsbæk Thuesen, Runa Vavia Fenger, et al
Volume
12
Issue
2
Pages
e0171525
DOI
https://dx.plos.org/10.1371/journal.pone.0171525
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171525
Scopus
85012077042
Mendeley
http://www.mendeley.com/research/ige-sensitization-inhalant-allergens-risk-airway-infection-disease-populationbased-study
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Mendeley | Further Information

{"title"=>"IgE sensitization to inhalant allergens and the risk of airway infection and disease: A population-based study", "type"=>"journal", "authors"=>[{"first_name"=>"Tea", "last_name"=>"Skaaby", "scopus_author_id"=>"55339779500"}, {"first_name"=>"Lise Lotte Nystrup", "last_name"=>"Husemoen", "scopus_author_id"=>"6507212941"}, {"first_name"=>"Betina Heinsb�k", "last_name"=>"Thuesen", "scopus_author_id"=>"57201144621"}, {"first_name"=>"Runa Vavia", "last_name"=>"Fenger", "scopus_author_id"=>"26221087800"}, {"first_name"=>"Allan", "last_name"=>"Linneberg", "scopus_author_id"=>"55624798600"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85012077042", "sgr"=>"85012077042", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0171525", "pmid"=>"28182643", "isbn"=>"1111111111", "pui"=>"614362932"}, "id"=>"7a113def-ed3b-35c6-b6ad-fb83716e3a00", "abstract"=>"BACKGROUND Immunoglobulin E (IgE) sensitization, which is the propensity to develop IgE antibodies against common environmental allergens, is associated with a lymphocyte T-helper type 2 (Th2) skewed immune response and a high risk of allergic respiratory disease. Little is known about whether IgE sensitization confers an increased risk of respiratory infections in adults. We investigated the association between IgE sensitization and the incidence of acute airway infections, other infections and chronic lower airway disease events as recorded in nation-wide registries. METHODS We included 14,849 persons from five population-based studies with measurements of serum specific IgE positivity against inhalant allergens. Participants were followed by linkage to Danish national registries (median follow-up time 11.3 years). The study-specific relative risks were estimated by Cox regression analysis, meta-analysed, and expressed as hazard ratios, HRs (95% confidence intervals, CIs). RESULTS The relative risks for IgE sensitized vs. non-sensitized were: for pneumonia (HR = 1.20, 95% CI: 1.01, 1.41), other acute airway infection (HR = 0.86, 95% CI: 0.60, 1.22), infection (HR = 1.06, 95% CI: 0.90, 1.24), asthma (HR = 2.26, 95% CI: 1.79, 2.86), and other chronic lower airway disease (HR = 1.31, 95% CI: 1.08, 1.58). In never smokers, the higher risk of pneumonia (HR = 1.73, 95% CI: 1.23, 2.44) and asthma (HR = 3.17, 95% CI: 2.10, 4.76) among IgE sensitized was more pronounced. CONCLUSIONS IgE sensitization was associated with a higher risk of asthma, other chronic lower airway diseases, and pneumonia. However, the association between IgE sensitization and pneumonia may be explained by undiagnosed asthma causing the pneumonia. Further studies are needed for confirmation.", "link"=>"http://www.mendeley.com/research/ige-sensitization-inhalant-allergens-risk-airway-infection-disease-populationbased-study", "reader_count"=>5, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Student > Bachelor"=>1, "Lecturer > Senior Lecturer"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>3, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>3}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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