Transcriptomic meta-analysis reveals up-regulation of gene expression functional in osteoclast differentiation in human septic shock
Publication Date
February 15, 2017
Authors
Samanwoy Mukhopadhyay, Pravat K. Thatoi, Abhay D. Pandey, Bidyut K. Das, et al
Volume
12
Issue
2
Pages
e0171689
DOI
https://dx.plos.org/10.1371/journal.pone.0171689
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171689
Scopus
85012977987
Mendeley
http://www.mendeley.com/research/transcriptomic-metaanalysis-reveals-upregulation-gene-expression-functional-osteoclast-differentiati
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Mendeley | Further Information

{"title"=>"Transcriptomic meta-analysis reveals upregulation of gene expression functional in osteoclast differentiation in human Septic shock", "type"=>"journal", "authors"=>[{"first_name"=>"Samanwoy", "last_name"=>"Mukhopadhyay", "scopus_author_id"=>"57193322090"}, {"first_name"=>"Pravat K.", "last_name"=>"Thatoi", "scopus_author_id"=>"55789629400"}, {"first_name"=>"Abhay D.", "last_name"=>"Pandey", "scopus_author_id"=>"57193321876"}, {"first_name"=>"Bidyut K.", "last_name"=>"Das", "scopus_author_id"=>"33767657500"}, {"first_name"=>"Balachandran", "last_name"=>"Ravindran", "scopus_author_id"=>"7005658998"}, {"first_name"=>"Samsiddhi", "last_name"=>"Bhattacharjee", "scopus_author_id"=>"15755159300"}, {"first_name"=>"Saroj K.", "last_name"=>"Mohapatra", "scopus_author_id"=>"26021386500"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"doi"=>"10.1371/journal.pone.0171689", "sgr"=>"85012977987", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85012977987", "issn"=>"19326203", "pui"=>"614431821"}, "id"=>"1a936f06-d376-379b-b0cb-175362c2134d", "abstract"=>"Septic shock is a major medical problem with high morbidity and mortality and incompletely understood biology. Integration of multiple data sets into a single analysis framework empowers discovery of new knowledge about the condition that may have been missed by individual analysis of each of these datasets. Electronic search was performed on medical literature and gene expression databases for selection of transcriptomic studies done in circulating leukocytes from human subjects suffering from septic shock. Gene-level meta-analysis was conducted on the six selected studies to identify the genes consistently differentially expressed in septic shock. This was followed by pathway-level analysis using three different algorithms (ORA, GSEA, SPIA). The identified up-regulated pathway, Osteoclast differentiation pathway (hsa04380) was validated in two independent cohorts. Of the pathway, 25 key genes were selected that serve as an expression signature of Septic Shock.Copyright © 2017 Mukhopadhyay et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/transcriptomic-metaanalysis-reveals-upregulation-gene-expression-functional-osteoclast-differentiati", "reader_count"=>5, "reader_count_by_academic_status"=>{"Researcher"=>1, "Student > Postgraduate"=>2, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Researcher"=>1, "Student > Postgraduate"=>2, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Medicine and Dentistry"=>2, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Psychology"=>{"Psychology"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}}, "group_count"=>2}

Scopus | Further Information

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