Cystatin F is a biomarker of prion pathogenesis in mice
Publication Date
February 08, 2017
Authors
Mario Nuvolone, Nicolas Schmid, Gino Miele, Silvia Sorce, et al
Volume
12
Issue
2
Pages
e0171923
DOI
https://dx.plos.org/10.1371/journal.pone.0171923
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0171923
Scopus
85012113218
Mendeley
http://www.mendeley.com/research/cystatin-f-biomarker-prion-pathogenesis-mice
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Mendeley | Further Information

{"title"=>"Cystatin F is a biomarker of prion pathogenesis in mice", "type"=>"journal", "authors"=>[{"first_name"=>"Mario", "last_name"=>"Nuvolone", "scopus_author_id"=>"14039439100"}, {"first_name"=>"Nicolas", "last_name"=>"Schmid", "scopus_author_id"=>"57193262702"}, {"first_name"=>"Gino", "last_name"=>"Miele", "scopus_author_id"=>"7006490391"}, {"first_name"=>"Silvia", "last_name"=>"Sorce", "scopus_author_id"=>"24472370800"}, {"first_name"=>"Rita", "last_name"=>"Moos", "scopus_author_id"=>"55007380800"}, {"first_name"=>"Christian", "last_name"=>"Schori", "scopus_author_id"=>"56562883100"}, {"first_name"=>"Roger R.", "last_name"=>"Beerli", "scopus_author_id"=>"6603743916"}, {"first_name"=>"Monika", "last_name"=>"Bauer", "scopus_author_id"=>"55430206300"}, {"first_name"=>"Philippe", "last_name"=>"Saudan", "scopus_author_id"=>"8885516000"}, {"first_name"=>"Klaus", "last_name"=>"Dietmeier", "scopus_author_id"=>"36904582900"}, {"first_name"=>"Ingolf", "last_name"=>"Lachmann", "scopus_author_id"=>"6603087725"}, {"first_name"=>"Michael", "last_name"=>"Linnebank", "scopus_author_id"=>"55676565500"}, {"first_name"=>"Roland", "last_name"=>"Martin", "scopus_author_id"=>"7501383358"}, {"first_name"=>"Ulf", "last_name"=>"Kallweit", "scopus_author_id"=>"21834259500"}, {"first_name"=>"Veronika", "last_name"=>"Kana", "scopus_author_id"=>"23034852800"}, {"first_name"=>"Elisabeth J.", "last_name"=>"Rushing", "scopus_author_id"=>"7004260158"}, {"first_name"=>"Herbert", "last_name"=>"Budka", "scopus_author_id"=>"22937182300"}, {"first_name"=>"Adriano", "last_name"=>"Aguzzi", "scopus_author_id"=>"7102605630"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"scopus"=>"2-s2.0-85012113218", "sgr"=>"85012113218", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0171923", "pmid"=>"28178353", "isbn"=>"1111111111", "pui"=>"614348135"}, "id"=>"a511cc15-9d3b-3f43-961e-b63971e513a9", "abstract"=>"Misfolding of the cellular prion protein (PrPC) into the scrapie prion protein (PrPSc) results in progressive, fatal, transmissible neurodegenerative conditions termed prion diseases. Experimental and epidemiological evidence point toward a protracted, clinically silent phase in prion diseases, yet there is no diagnostic test capable of identifying asymptomatic individuals incubating prions. In an effort to identify early biomarkers of prion diseases, we have compared global transcriptional profiles in brains from pre-symptomatic prion-infected mice and controls. We identified Cst7, which encodes cystatin F, as the most strongly upregulated transcript in this model. Early and robust upregulation of Cst7 mRNA levels and of its cognate protein was validated in additional mouse models of prion disease. Surprisingly, we found no significant increase in cystatin F levels in both cerebrospinal fluid or brain parenchyma of patients with Creutzfeldt-Jakob disease compared to Alzheimer's disease or non-demented controls. Our results validate cystatin F as a useful biomarker of early pathogenesis in experimental models of prion disease, and point to unexpected species-specific differences in the transcriptional responses to prion infections.", "link"=>"http://www.mendeley.com/research/cystatin-f-biomarker-prion-pathogenesis-mice", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>1, "Professor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>3, "Student > Postgraduate"=>3, "Student > Master"=>1, "Professor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Biochemistry, Genetics and Molecular Biology"=>3, "Agricultural and Biological Sciences"=>5, "Medicine and Dentistry"=>2, "Neuroscience"=>2, "Chemistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Neuroscience"=>{"Neuroscience"=>2}, "Chemistry"=>{"Chemistry"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>5}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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