A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery
Publication Date
March 16, 2017
Authors
Behzad Amoozgar, Xiaoling Wei, Jun Hui Lee, Michele Bloomer, et al
Volume
12
Issue
3
Pages
e0172556
DOI
https://dx.plos.org/10.1371/journal.pone.0172556
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172556
Scopus
85015457169
Mendeley
http://www.mendeley.com/research/novel-flexible-microfluidic-meshwork-reduce-fibrosis-glaucoma-surgery
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Mendeley | Further Information

{"title"=>"A novel flexible microfluidic meshwork to reduce fibrosis in glaucoma surgery", "type"=>"journal", "authors"=>[{"first_name"=>"Behzad", "last_name"=>"Amoozgar", "scopus_author_id"=>"37033332400"}, {"first_name"=>"Xiaoling", "last_name"=>"Wei", "scopus_author_id"=>"57192436609"}, {"first_name"=>"Jun Hui", "last_name"=>"Lee", "scopus_author_id"=>"57192666813"}, {"first_name"=>"Michele", "last_name"=>"Bloomer", "scopus_author_id"=>"6603870121"}, {"first_name"=>"Zhengtuo", "last_name"=>"Zhao", "scopus_author_id"=>"57193645524"}, {"first_name"=>"Paul", "last_name"=>"Coh", "scopus_author_id"=>"56671370300"}, {"first_name"=>"Fei", "last_name"=>"He", "scopus_author_id"=>"57193644382"}, {"first_name"=>"Lan", "last_name"=>"Luan", "scopus_author_id"=>"57193647519"}, {"first_name"=>"Chong", "last_name"=>"Xie", "scopus_author_id"=>"57192426893"}, {"first_name"=>"Ying", "last_name"=>"Han", "scopus_author_id"=>"55489199300"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1111111111", "sgr"=>"85015457169", "doi"=>"10.1371/journal.pone.0172556", "pui"=>"614831719", "scopus"=>"2-s2.0-85015457169", "issn"=>"19326203", "pmid"=>"28301490"}, "id"=>"95c8531f-82d7-3e2f-81e2-a40a1698aa80", "abstract"=>"PURPOSE/RELEVANCE: Fibrosis and hence capsule formation around the glaucoma implants are the main reasons for glaucoma implant failure. To address these issues, we designed a microfluidic meshwork and tested its biocompatibility in a rabbit eye model. The amount of fibrosis elicited by the microfluidic meshwork was compared to the amount elicited by the plate of conventional glaucoma drainage device. METHODS: Six eyes from 3 New Zealand albino rabbits were randomized to receive either the novel microfluidic meshwork or a plate of Ahmed glaucoma valve model PF7 (AGV PF7). The flexible microfluidic implant was made from negative photoresist SU-8 by using micro-fabrication techniques. The overall size of the meshwork was 7 mm x 7 mm with a grid period of 100 mum. Both implants were placed in the subtenon space at the supratemporal quadrant in a standard fashion. There was no communication between the implants and the anterior chamber via a tube. All animal eyes were examined for signs of infection and implant erosion on days 1, 3, 7, and 14 and then monthly. Exenterations were performed in which the entire orbital contents were removed at 3 months. Histology slides of the implant and the surrounding tissues were prepared and stained with hematoxylin-eosin. Thickness of the fibrous capsules beneath the implants were measured and compared with paired student's t-test between the two groups. RESULTS: The gross histological sections showed that nearly no capsule formed around the microfluidic meshwork in contrast to the thick capsule formed around the plate of AGV PF7. Thickness of the fibrotic capsules beneath the AGV PF7 plate from the 3 rabbit eyes was 90mum, 82mum, and 95 mum, respectively. The thickness at the bottom of fibrotic capsules around the new microfluidic implant were 1mum, 2mum, and 1mum, respectively. The difference in thickness of capsule between the two groups was significant (P = 0.002). No complications were noticed in the 6 eyes, and both implants were tolerated well by all rabbits. CONCLUSION: The microfluidic meshwork elicited minimal fibrosis and capsule formation after 3-months implantation in a rabbit model. This provides promising evidence to aid in future development of a new glaucoma drainage implant that will elicit minimal scar formation and provide better long-term surgical outcomes.", "link"=>"http://www.mendeley.com/research/novel-flexible-microfluidic-meshwork-reduce-fibrosis-glaucoma-surgery", "reader_count"=>8, "reader_count_by_academic_status"=>{"Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_user_role"=>{"Librarian"=>1, "Student > Doctoral Student"=>3, "Researcher"=>1, "Student > Master"=>2, "Professor"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>1, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>1}}, "reader_count_by_country"=>{"Colombia"=>1}, "group_count"=>1}

Scopus | Further Information

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