A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity
Publication Date
February 23, 2017
Authors
Tuki Attuquayefio, Richard J. Stevenson, Megan J. Oaten & Heather M. Francis
Volume
12
Issue
2
Pages
e0172645
DOI
https://dx.plos.org/10.1371/journal.pone.0172645
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172645
Scopus
85013659631
Mendeley
http://www.mendeley.com/research/fourday-westernstyle-dietary-intervention-causes-reductions-hippocampaldependent-learning-memory-int
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Mendeley | Further Information

{"title"=>"A four-day Western-style dietary intervention causes reductions in hippocampal-dependent learning and memory and interoceptive sensitivity", "type"=>"journal", "authors"=>[{"first_name"=>"Tuki", "last_name"=>"Attuquayefio", "scopus_author_id"=>"55955606000"}, {"first_name"=>"Richard J.", "last_name"=>"Stevenson", "scopus_author_id"=>"7402603332"}, {"first_name"=>"Megan J.", "last_name"=>"Oaten", "scopus_author_id"=>"8343256100"}, {"first_name"=>"Heather M.", "last_name"=>"Francis", "scopus_author_id"=>"39161283300"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"614522436", "sgr"=>"85013659631", "issn"=>"19326203", "pmid"=>"28231304", "scopus"=>"2-s2.0-85013659631", "doi"=>"10.1371/journal.pone.0172645", "isbn"=>"1111111111"}, "id"=>"27c49ae4-a979-3bbd-b812-e78a9e5c9439", "abstract"=>"In animals, a Western style diet–high in saturated fat and added sugar–causes impairments in hippocampal-dependent learning and memory (HDLM) and perception of internal bodily state (interoception). In humans, while there is correlational support for a link between West- ern-style diet, HDLM, and interoception, there is as yet no causal data. Here, healthy individ- uals were randomly assigned to consume either a breakfast high in saturated fat and added sugar (Experimental condition) or a healthier breakfast (Control condition), over four conse- cutive days. Tests of HDLM, interoception and biological measures were administered before and after breakfast on the days one and four, and participants completed food diaries before and during the study. At the end of the study, the Experimental condition showed significant reductions in HDLM and reduced interoceptive sensitivity to hunger and fullness, relative to the Control condition. The Experimental condition also showed a markedly differ- ent blood glucose and triglyceride responses to their breakfast, relative to Controls, with larger changes in blood glucose across breakfast being associated with greater reductions in HDLM. The Experimental condition compensated for their energy-dense breakfast by reducing carbohydrate intake, while saturated fat intake remained consistently higher than Controls. This is the first experimental study in humans to demonstrate that a Western-style diet impacts HDLM following a relatively short exposure–just as in animals. The link be- tween diet-induced HDLM changes and blood glucose suggests one pathway by which diet impacts HDLM in humans.", "link"=>"http://www.mendeley.com/research/fourday-westernstyle-dietary-intervention-causes-reductions-hippocampaldependent-learning-memory-int", "reader_count"=>22, "reader_count_by_academic_status"=>{"Researcher"=>2, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Student > Bachelor"=>6, "Unspecified"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_user_role"=>{"Researcher"=>2, "Student > Ph. D. Student"=>8, "Student > Master"=>4, "Student > Bachelor"=>6, "Unspecified"=>1, "Student > Doctoral Student"=>1}, "reader_count_by_subject_area"=>{"Nursing and Health Professions"=>5, "Medicine and Dentistry"=>1, "Neuroscience"=>2, "Sports and Recreations"=>2, "Psychology"=>10, "Economics, Econometrics and Finance"=>1, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Neuroscience"=>{"Neuroscience"=>2}, "Sports and Recreations"=>{"Sports and Recreations"=>2}, "Psychology"=>{"Psychology"=>10}, "Economics, Econometrics and Finance"=>{"Economics, Econometrics and Finance"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>5}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>1}

Scopus | Further Information

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