Prevalence of HPV 16 and 18 and attitudes toward HPV vaccination trials in patients with cervical cancer in Mali
Publication Date
February 23, 2017
Journal
PLOS ONE
Authors
Ibrahima Téguété, Amadou Dolo, Kotou Sangare, Abdoulaye Sissoko, et al
Volume
12
Issue
2
Pages
e0172661
DOI
https://dx.plos.org/10.1371/journal.pone.0172661
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172661
Scopus
85013652256
Mendeley
http://www.mendeley.com/research/prevalence-hpv-16-18-attitudes-toward-hpv-vaccination-trials-patients-cervical-cancer-mali-2
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Mendeley | Further Information

{"title"=>"Prevalence of HPV 16 and 18 and attitudes toward HPV vaccination trials in patients with cervical cancer in Mali", "type"=>"journal", "authors"=>[{"first_name"=>"Ibrahima", "last_name"=>"Téguété", "scopus_author_id"=>"57195374223"}, {"first_name"=>"Amadou", "last_name"=>"Dolo", "scopus_author_id"=>"24281149000"}, {"first_name"=>"Kotou", "last_name"=>"Sangare", "scopus_author_id"=>"55443460600"}, {"first_name"=>"Abdoulaye", "last_name"=>"Sissoko", "scopus_author_id"=>"57193403422"}, {"first_name"=>"Mali", "last_name"=>"Rochas", "scopus_author_id"=>"55604188000"}, {"first_name"=>"Sarah", "last_name"=>"Beseme", "scopus_author_id"=>"57063408200"}, {"first_name"=>"Karamoko", "last_name"=>"Tounkara", "scopus_author_id"=>"57194730667"}, {"first_name"=>"Shahla", "last_name"=>"Yekta", "scopus_author_id"=>"55603915300"}, {"first_name"=>"Anne S.", "last_name"=>"De Groot", "scopus_author_id"=>"7202864343"}, {"first_name"=>"Ousmane A.", "last_name"=>"Koita", "scopus_author_id"=>"6506166177"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85013652256", "doi"=>"10.1371/journal.pone.0172661", "issn"=>"19326203", "pui"=>"614522431", "isbn"=>"1111111111", "pmid"=>"28231334", "scopus"=>"2-s2.0-85013652256"}, "id"=>"f3473e31-56cf-3e25-8b4b-6feabc3bc07b", "abstract"=>"BACKGROUND Cervical cancer is one of the most common and lethal cancers in West Africa. Even though vaccines that protect against the most common Human papillomavirus (HPV) strains, 16 and 18, are currently in use in developed countries, the implementation of these vaccines in developing countries has been painfully slow, considering the pre-eminence of HPV-associated cervical cancer among women in those countries. AIM We performed serological and PCR-based assessment of blood and tissue specimens obtained from women undergoing cervical cancer-related surgery at a major urban hospital in Bamako. Since several therapeutic HPV vaccines are currently in clinical trials, we also assessed willingness to participate in HPV cancer vaccine trials. METHODS Blood and biopsy samples of 240 women were evaluated for HPV types 16 and 18 by serology and PCR. Knowledge regarding the HPV vaccine and autonomy to decide to vaccinate their own child was assessed with a standardized questionnaire. RESULTS HPV 16 and 18 were identified in 137/166 (82.5%) cervical cancer biopsy samples by PCR. Co-infection with both HPV 16 and 18 was significantly more frequent in women over 50 years of age than in younger women (63.0% vs. 37.0%). 44% of study participants said they would be willing to vaccinate their child with HPV vaccine. Only 39% of women participating in this study reported that they would be able to make an autonomous decision to receive HPV vaccination. Permission from a male spouse or head of household was identified as important for participation by 59% of the women. CONCLUSION This study provides strong support for the introduction of currently available HPV vaccines in Mali, and also provides key information about conditions for obtaining informed consent for HPV vaccine trials and HPV vaccination in Mali.", "link"=>"http://www.mendeley.com/research/prevalence-hpv-16-18-attitudes-toward-hpv-vaccination-trials-patients-cervical-cancer-mali-2", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>2, "Student > Doctoral Student"=>1, "Student > Master"=>3, "Other"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>3, "Medicine and Dentistry"=>1, "Agricultural and Biological Sciences"=>1, "Social Sciences"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Social Sciences"=>{"Social Sciences"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>3}, "Unspecified"=>{"Unspecified"=>3}}, "group_count"=>1}

Scopus | Further Information

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