Molecular typing of Treponema pallidum isolates from Buenos Aires, Argentina: Frequent Nichols-like isolates and low levels of macrolide resistance
Publication Date
February 24, 2017
Authors
Lucía Gallo Vaulet, Linda Grillová, Lenka Mikalová, Ricardo Casco, et al
Volume
12
Issue
2
Pages
e0172905
DOI
https://dx.plos.org/10.1371/journal.pone.0172905
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0172905
Scopus
85014012267
Mendeley
http://www.mendeley.com/research/molecular-typing-treponema-pallidum-isolates-buenos-aires-argentina-frequent-nicholslike-isolates-lo
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Mendeley | Further Information

{"title"=>"Molecular typing of treponema pallidum isolates from buenos aires, Argentina: Frequent nichols-like isolates and low levels of macrolide resistance", "type"=>"journal", "authors"=>[{"first_name"=>"Lucía Gallo", "last_name"=>"Vaulet", "scopus_author_id"=>"35176596400"}, {"first_name"=>"Linda", "last_name"=>"Grillová", "scopus_author_id"=>"56156311900"}, {"first_name"=>"Lenka", "last_name"=>"Mikalová", "scopus_author_id"=>"36717991200"}, {"first_name"=>"Ricardo", "last_name"=>"Casco", "scopus_author_id"=>"6602793231"}, {"first_name"=>"Marcelo Rodríguez", "last_name"=>"Fermepin", "scopus_author_id"=>"6506165555"}, {"first_name"=>"María A.", "last_name"=>"Pando", "scopus_author_id"=>"7003693725"}, {"first_name"=>"David", "last_name"=>"Šmajs", "scopus_author_id"=>"6603422324"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"614547874", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0172905", "sgr"=>"85014012267", "isbn"=>"1111111111", "pmid"=>"28235102", "scopus"=>"2-s2.0-85014012267"}, "id"=>"92b9cf71-3b1c-3700-940f-7c1a06777463", "abstract"=>"A total of 54 clinical samples, including genital lesion swabs, whole blood and cerebrospinal fluid from patients diagnosed with syphilis were collected in 2006 and in 2013 in Buenos Aires, Argentina. Treponemal DNA was detected in 43 of the analyzed samples (79.6%) and further analyzed using Sequencing-based molecular typing (SBMT) and Enhanced CDC-typing (ECDCT). By SBMT, 10 different Treponema pallidum subsp. pallidum (TPA) genotypes were found, of which six were related to the TPA SS14 strain, and four to the TPA Nichols strain. The 23S rRNA gene was amplified in samples isolated from 42 patients, and in six of them (14.3%), either the A2058G (four patients, 9.5%) or the A2059G (two patients, 4.8%) mutations were found. In addition to Taiwan, Madagascar and Peru, Argentina is another country where the prevalence of Nichols-like isolates (26.8%) is greater than 10%.", "link"=>"http://www.mendeley.com/research/molecular-typing-treponema-pallidum-isolates-buenos-aires-argentina-frequent-nicholslike-isolates-lo", "reader_count"=>5, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Other"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Unspecified"=>1}, "reader_count_by_subject_area"=>{"Biochemistry, Genetics and Molecular Biology"=>2, "Agricultural and Biological Sciences"=>2, "Unspecified"=>1}, "reader_count_by_subdiscipline"=>{"Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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