Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function
Publication Date
March 02, 2017
Authors
Christian Shetelig, Shanmuganathan Limalanathan, Jan Eritsland, Pavel Hoffmann, et al
Volume
12
Issue
3
Pages
e0173034
DOI
https://dx.plos.org/10.1371/journal.pone.0173034
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173034
Scopus
85014479522
Mendeley
http://www.mendeley.com/research/osteoprotegerin-levels-stelevation-myocardial-infarction-temporal-profile-association-myocardial-inj
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Mendeley | Further Information

{"title"=>"Osteoprotegerin levels in ST-elevation myocardial infarction: Temporal profile and association with myocardial injury and left ventricular function", "type"=>"journal", "authors"=>[{"first_name"=>"Christian", "last_name"=>"Shetelig", "scopus_author_id"=>"57193509687"}, {"first_name"=>"Shanmuganathan", "last_name"=>"Limalanathan", "scopus_author_id"=>"36181324800"}, {"first_name"=>"Jan", "last_name"=>"Eritsland", "scopus_author_id"=>"56094470100"}, {"first_name"=>"Pavel", "last_name"=>"Hoffmann", "scopus_author_id"=>"19835135500"}, {"first_name"=>"Ingebjørg", "last_name"=>"Seljeflot", "scopus_author_id"=>"7004554311"}, {"first_name"=>"Jon Michael", "last_name"=>"Gran", "scopus_author_id"=>"36859333900"}, {"first_name"=>"Pål", "last_name"=>"Aukrust", "scopus_author_id"=>"56771586600"}, {"first_name"=>"Thor", "last_name"=>"Ueland", "scopus_author_id"=>"7007162539"}, {"first_name"=>"Geir Øystein", "last_name"=>"Andersen", "scopus_author_id"=>"56027612500"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"sgr"=>"85014479522", "pmid"=>"28253327", "pui"=>"614645228", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85014479522", "doi"=>"10.1371/journal.pone.0173034", "issn"=>"19326203"}, "id"=>"f559cc2c-4459-3851-8e32-3e2cfe9248d8", "abstract"=>"BACKGROUND: Elevated levels of osteoprotegerin (OPG) have been associated with adverse outcomes in ST-elevation myocardial infarction (STEMI). However, the role of OPG in myocardial injury and adverse remodeling in STEMI patients remains unclear. The aims of this observational cohort study were to evaluate: 1) the temporal profile of OPG during STEMI, 2) possible associations between OPG measured acutely and after 4 months, with infarct size, adverse left ventricular (LV) remodeling, microvascular obstruction (MVO) and myocardial salvage and 3) the effect of heparin administration on OPG levels. METHODS: Blood samples were drawn repeatedly from 272 STEMI patients treated with primary percutaneous coronary intervention (PCI). Cardiac magnetic resonance imaging (CMR) was performed in the acute phase and after 4 months. The effect of heparin administration on OPG levels was studied in 20 patients referred to elective coronary angiography. RESULTS: OPG levels measured acutely were significantly higher than Day 1 and during follow-up. OPG levels were correlated with age. No association was found between early OPG levels and CMR measurements at 4 months. Patients with >median OPG levels measured at Day 1 had larger final infarct size, lower LV ejection fraction (LVEF) at 4 months and higher frequency of MVO. There were no associations between OPG and change in end-diastolic volume or myocardial salvage. OPG remained associated with infarct size and LVEF after adjustment for relevant covariates, except peak troponin T and CRP. A 77% increase in OPG levels following heparin administration was found in patients undergoing elective coronary angiography. CONCLUSIONS: OPG was found to be associated with myocardial injury, but not with LV remodeling or myocardial salvage. The use of OPG as a biomarker in STEMI patients seems to be limited by a strong association with age, confounding effect of heparin administration, and little additive value to established biomarkers.", "link"=>"http://www.mendeley.com/research/osteoprotegerin-levels-stelevation-myocardial-infarction-temporal-profile-association-myocardial-inj", "reader_count"=>2, "reader_count_by_academic_status"=>{"Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Other"=>1, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}}, "group_count"=>0}

Scopus | Further Information

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