Screening gestational diabetes mellitus: The role of maternal age
Publication Date
March 15, 2017
Authors
Chun Heng Kuo, Szu Chi Chen, Chi Tai Fang, Feng Jung Nien, et al
Volume
12
Issue
3
Pages
e0173049
DOI
https://dx.plos.org/10.1371/journal.pone.0173049
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173049
Scopus
85015332814
Mendeley
http://www.mendeley.com/research/screening-gestational-diabetes-mellitus-role-maternal-age-2
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Mendeley | Further Information

{"title"=>"Screening gestational diabetes mellitus: The role of maternal age", "type"=>"journal", "authors"=>[{"first_name"=>"Chun-Heng", "last_name"=>"Kuo"}, {"first_name"=>"Szu-Chi", "last_name"=>"Chen"}, {"first_name"=>"Chi-Tai", "last_name"=>"Fang"}, {"first_name"=>"Feng-Jung", "last_name"=>"Nien"}, {"first_name"=>"En-Tzu", "last_name"=>"Wu"}, {"first_name"=>"Shin-Yu", "last_name"=>"Lin"}, {"first_name"=>"Lee-Ming", "last_name"=>"Chuang"}, {"first_name"=>"Chien-Nan", "last_name"=>"Lee"}, {"first_name"=>"Hung-Yuan", "last_name"=>"Li"}], "year"=>2017, "source"=>"Plos One", "identifiers"=>{"doi"=>"10.1371/journal.pone.0173049", "issn"=>"1932-6203", "pmid"=>"28296923", "isbn"=>"1111111111"}, "id"=>"29498485-281c-3312-b6d4-9261c58a4f36", "abstract"=>"Objective\r\nUsing a specific cutoff of fasting plasma glucose (FPG) to screen gestational diabetes mellitus\r\n(GDM) can reduce the use of oral glucose tolerance tests (OGTT). Since the prevalence\r\nof GDM increases with age, this screening method may not be appropriate in healthcare\r\nsystems where women become pregnant at older ages. Therefore, we aimed to develop a\r\nscreening algorithm for GDM that takes maternal age into consideration.\r\n\r\nMethods\r\nWe included 945 pregnant women without history of GDM who received 75g OGTT to diagnose\r\nGDM in 2011. Screening algorithms using FPG with or without age were developed.\r\nAnother 362 pregnant women were recruited in 2013–2015 as the validation cohort.\r\n\r\nResults\r\nUsing FPG criteria alone, more GDM diagnoses were missed in women \u001535 years than in\r\nwomen <35 years (13.2% vs. 5.8%, p <0.001). Among GDM women \u001535 years, 63.6% had\r\nFPG <92 mg/dL (5.1 mmol/L). Use of the algorithm with an “age plus FPG” cutoff could\r\nreduce the use of OGTT (OGTT%) from 77.6% to 62.9%, while maintaining good sensitivity\r\n(from 91.9% to 90.2%) and specificity (from 100% to 100%). Similar reduction in OGTT%\r\nwas found in the validation cohort (from 86.4% to 76.8%). In the simulation, if the percentage\r\nof women \u001535 years were 40% or more, the screening algorithm with an “age plus FPG”\r\ncutoff could further reduce OGTT% by 11.0%-18.8%.\r\n\r\nConclusions\r\nA screening algorithm for GDM that takes maternal age into consideration can reduce the\r\nuse of OGTT when women become pregnant at older ages.", "link"=>"http://www.mendeley.com/research/screening-gestational-diabetes-mellitus-role-maternal-age-2", "reader_count"=>15, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>5}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Researcher"=>1, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>4, "Student > Bachelor"=>5}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Nursing and Health Professions"=>2, "Medicine and Dentistry"=>5, "Agricultural and Biological Sciences"=>1, "Pharmacology, Toxicology and Pharmaceutical Science"=>3, "Social Sciences"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Social Sciences"=>{"Social Sciences"=>1}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>2}, "Unspecified"=>{"Unspecified"=>2}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>3}}, "group_count"=>2}

Scopus | Further Information

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