Renal function is independently associated with circulating betatrophin
Publication Date
March 03, 2017
Authors
Lukas Maurer, Franziska Schwarz, Antje Fischer Rosinsky, Nina Schlueter, et al
Volume
12
Issue
3
Pages
e0173197
DOI
https://dx.plos.org/10.1371/journal.pone.0173197
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173197
Scopus
85014427817
Mendeley
http://www.mendeley.com/research/renal-function-independently-associated-circulating-betatrophin
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Mendeley | Further Information

{"title"=>"Renal function is independently associated with circulating betatrophin", "type"=>"journal", "authors"=>[{"first_name"=>"Lukas", "last_name"=>"Maurer", "scopus_author_id"=>"55228435300"}, {"first_name"=>"Franziska", "last_name"=>"Schwarz", "scopus_author_id"=>"36700430100"}, {"first_name"=>"Antje", "last_name"=>"Fischer-Rosinsky", "scopus_author_id"=>"25824780800"}, {"first_name"=>"Nina", "last_name"=>"Schlueter", "scopus_author_id"=>"55611718000"}, {"first_name"=>"Sebastian", "last_name"=>"Brachs", "scopus_author_id"=>"57193509841"}, {"first_name"=>"Matthias", "last_name"=>"Möhlig", "scopus_author_id"=>"56785697400"}, {"first_name"=>"Andreas", "last_name"=>"Pfeiffer", "scopus_author_id"=>"22836540000"}, {"first_name"=>"Knut", "last_name"=>"Mai", "scopus_author_id"=>"55598827300"}, {"first_name"=>"Joachim", "last_name"=>"Spranger", "scopus_author_id"=>"55101740600"}, {"first_name"=>"Thomas", "last_name"=>"Bobbert", "scopus_author_id"=>"8524047800"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"614652162", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85014427817", "sgr"=>"85014427817", "issn"=>"19326203", "doi"=>"10.1371/journal.pone.0173197", "pmid"=>"28257453"}, "id"=>"c8e09717-5748-3979-8821-d0c4bdc08864", "abstract"=>"OBJECTIVE: Betatrophin has been identified as a marker linking liver with beta cell function and lipid metabolism in murine models. Until now, the regulation of circulating betatrophin in humans is not entirely clear. We here analyzed the relation of betatrophin levels to phenotypes of the metabolic syndrome and speculated that renal function might influence circulating betatrophin levels and explain age-dependent changes of betatrophin. SUBJECTS: We analyzed blood samples from 535 individuals participating in the Metabolic Syndrome Berlin Potsdam study. RESULTS: In a crude analysis we found a positive correlation between betatrophin levels and HbA1c (r = 0.24; p < 0.001), fasting glucose (r = 0.20; p < 0.001) and triglycerides (r = 0.12; p = 0.007). Furthermore betatrophin was positively correlated with age (r = 0.47; p <0.001), systolic blood pressure (r = 0.17; p < 0.001), intima media thickness (r = 0.26; p < 0.001) and negatively correlated with CKD-EPI eGFR (r = -0.33; p < 0.001) as an estimate of renal function. Notably, eGFR remained highly associated with betatrophin after adjustment for age, waist circumference, gender, HbA1c and lipid parameters in a multivariate linear regression model (beta = -0.197, p< 0.001). CONCLUSIONS: Our data suggest that circulating levels of betatrophin depend on age, gender, waist circumference, total/HDL cholesterol ratio and renal function. Especially the association to eGFR highlights the importance for future studies to address renal function as possible influence on betatrophin regulation and consider eGFR as potential confounder when analyzing the role of betatrophin in humans.", "link"=>"http://www.mendeley.com/research/renal-function-independently-associated-circulating-betatrophin", "reader_count"=>5, "reader_count_by_academic_status"=>{"Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Student > Doctoral Student"=>1, "Student > Postgraduate"=>1, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Agricultural and Biological Sciences"=>2, "Medicine and Dentistry"=>2}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>2}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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