Natalizumab stabilizes physical, cognitive, MRI, and OCT markers of disease activity: A prospective, non-randomized pilot study
Publication Date
April 20, 2017
Authors
Garrick D. Talmage, Oscar J. M. Coppes, Adil Javed & Jacqueline Bernard
Volume
12
Issue
4
Pages
e0173299
DOI
https://dx.plos.org/10.1371/journal.pone.0173299
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173299
Scopus
85017681973
Mendeley
http://www.mendeley.com/research/natalizumab-stabilizes-physical-cognitive-mri-oct-markers-disease-activity-prospective-nonrandomized
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Mendeley | Further Information

{"title"=>"Natalizumab stabilizes physical, cognitive, MRI, and OCT markers of disease activity: A prospective, non-randomized pilotstudy", "type"=>"generic", "authors"=>[{"first_name"=>"Garrick D.", "last_name"=>"Talmage", "scopus_author_id"=>"57194053352"}, {"first_name"=>"Oscar J.M.", "last_name"=>"Coppes", "scopus_author_id"=>"25724077400"}, {"first_name"=>"Adil", "last_name"=>"Javed", "scopus_author_id"=>"24483341900"}, {"first_name"=>"Jacqueline", "last_name"=>"Bernard", "scopus_author_id"=>"7403164962"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"issn"=>"19326203", "pui"=>"615495674", "pmid"=>"28426702", "sgr"=>"85018525459", "doi"=>"10.1371/journal.pone.0173299", "isbn"=>"1932-6203", "scopus"=>"2-s2.0-85018525459"}, "id"=>"75ce7ce9-4ac4-3df6-aed3-ec572ab8f3b1", "abstract"=>"Natalizumab is an effective therapy for multiple sclerosis (MS). Its effectiveness has been demonstrated in several clinical and imaging studies. The objective of this study was to further demonstrate the efficacy of natalizumab using a comprehensive battery of clinical and imaging markers in the same cohort of patients followed longitudinally, hence capturing the multi-faceted nature of the MS disease process. A prospective, open-label, pilot study of 20 MS patients treated with natalizumab was conducted. High resolution MRI, Symbol-Digit Modalities Test (SDMT), and Optical Coherence Tomography (OCT) scans were obtained at baseline, 48, and 96 weeks. 15 patients completed the study. Natalizumab treatment decreased Expanded Disability Status Scale score (EDSS) and no change in SDMT, Brain Parenchymal Fraction (BPF), or any of the OCT markers of retinal degeneration was observed. Thalamic and whole brain volume as assessed by Percentage Brain Volume Change (PBVC) showed continuous deterioration. Higher baseline T2 lesion load correlated with increased rate of PBVC at 96-weeks (r = 0.566, R2 = 0.320, p = 0.035) and thalamic volume loss (r = -0.586, R2 = 0.344, p = 0.027). Most patients, 93%, achieved no evidence of disease activity (NEDA) at 2 years, likely due to early disease duration and lower initial baseline lesion load. This study further demonstrates stabilization of clinical and imaging markers of disease activity during natalizumab treatment.", "link"=>"http://www.mendeley.com/research/natalizumab-stabilizes-physical-cognitive-mri-oct-markers-disease-activity-prospective-nonrandomized", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Researcher"=>2, "Student > Ph. D. Student"=>1, "Student > Master"=>3, "Student > Bachelor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>2, "Medicine and Dentistry"=>5, "Psychology"=>1, "Neuroscience"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Neuroscience"=>{"Neuroscience"=>1}, "Psychology"=>{"Psychology"=>1}, "Unspecified"=>{"Unspecified"=>2}}, "group_count"=>0}

Scopus | Further Information

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