Nonalcoholic fatty liver disease and increased risk of 1-year all-cause and cardiac hospital readmissions in elderly patients admitted for acute heart failure
Publication Date
March 13, 2017
Authors
Filippo Valbusa, Stefano Bonapace, Davide Agnoletti, Luca Scala, et al
Volume
12
Issue
3
Pages
e0173398
DOI
https://dx.plos.org/10.1371/journal.pone.0173398
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173398
Scopus
85015277580
Mendeley
http://www.mendeley.com/research/nonalcoholic-fatty-liver-disease-increased-risk-1year-allcause-cardiac-hospital-readmissions-elderly-2
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Mendeley | Further Information

{"title"=>"Nonalcoholic fatty liver disease and increased risk of 1-year all-cause and cardiac hospital readmissions in elderly patients admitted for acute heart failure", "type"=>"journal", "authors"=>[{"first_name"=>"Filippo", "last_name"=>"Valbusa", "scopus_author_id"=>"25643542500"}, {"first_name"=>"Stefano", "last_name"=>"Bonapace", "scopus_author_id"=>"6602788249"}, {"first_name"=>"Davide", "last_name"=>"Agnoletti", "scopus_author_id"=>"24466223600"}, {"first_name"=>"Luca", "last_name"=>"Scala", "scopus_author_id"=>"12763862300"}, {"first_name"=>"Cristina", "last_name"=>"Grillo", "scopus_author_id"=>"57140059200"}, {"first_name"=>"Pietro", "last_name"=>"Arduini", "scopus_author_id"=>"57193629585"}, {"first_name"=>"Emanuela", "last_name"=>"Turcato", "scopus_author_id"=>"57193627998"}, {"first_name"=>"Alessandro", "last_name"=>"Mantovani", "scopus_author_id"=>"55838510687"}, {"first_name"=>"Giacomo", "last_name"=>"Zoppini", "scopus_author_id"=>"55398655800"}, {"first_name"=>"Guido", "last_name"=>"Arcaro", "scopus_author_id"=>"55935841000"}, {"first_name"=>"Christopher", "last_name"=>"Byrne", "scopus_author_id"=>"55603698800"}, {"first_name"=>"Giovanni", "last_name"=>"Targher", "scopus_author_id"=>"7003689424"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pmid"=>"28288193", "doi"=>"10.1371/journal.pone.0173398", "sgr"=>"85015277580", "isbn"=>"1111111111", "scopus"=>"2-s2.0-85015277580", "issn"=>"19326203", "pui"=>"614776879"}, "id"=>"eaa870a6-4376-33a4-bbb5-a79e921fc318", "abstract"=>"Nonalcoholic fatty liver disease (NAFLD) is an emerging risk factor for heart failure (HF). Although some progress has been made in improving survival among patients admitted for HF, the rates of hospital readmissions and the related costs continue to rise dramatically. We sought to examine whether NAFLD and its severity (diagnosed at hospital admission) was independently associated with a higher risk of 1-year all-cause and cardiac re-hospitalization in patients admitted for acute HF. We studied 212 elderly patients who were consecutively admitted with acute HF to the Hospital of Negrar (Verona) over a 1-year period. Diagnosis of NAFLD was based on ultrasonography, whereas the severity of advanced NAFLD fibrosis was based on the fibrosis (FIB)-4 score and other non-invasive fibrosis scores. Patients with acute myocardial infarction, severe valvular heart diseases, end-stage renal disease, cancer, known liver diseases or decompensated cirrhosis were excluded. Cox regression was used to estimate hazard ratios (HR) for the associations between NAFLD and the outcome(s) of interest. The cumulative rate of 1-year all-cause re-hospitalizations was 46.7% (n = 99, mainly due to cardiac causes). Patients with NAFLD (n = 109; 51.4%) had remarkably higher 1-year all-cause and cardiac re-hospitalization rates compared with their counterparts without NAFLD. Both event rates were particularly increased in those with advanced NAFLD fibrosis. NAFLD was associated with a 5-fold increased risk of 1-year all-cause re-hospitalization (adjusted-hazard ratio 5.05, 95% confidence intervals 2.78-9.10, p<0.0001) after adjustment for established risk factors and potential confounders. Similar results were found for 1-year cardiac re-hospitalization (adjusted-hazard ratio 8.05, 95% confidence intervals 3.77-15.8, p<0.0001). In conclusion, NAFLD and its severity were strongly and independently associated with an increased risk of 1-year all-cause and cardiac re-hospitalization in elderly patients admitted with acute HF.;", "link"=>"http://www.mendeley.com/research/nonalcoholic-fatty-liver-disease-increased-risk-1year-allcause-cardiac-hospital-readmissions-elderly-2", "reader_count"=>9, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Doctoral Student"=>1, "Student > Ph. D. Student"=>1, "Student > Postgraduate"=>1, "Other"=>2, "Student > Master"=>1, "Student > Bachelor"=>1, "Professor"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Engineering"=>1, "Nursing and Health Professions"=>1, "Medicine and Dentistry"=>5, "Psychology"=>1}, "reader_count_by_subdiscipline"=>{"Engineering"=>{"Engineering"=>1}, "Medicine and Dentistry"=>{"Medicine and Dentistry"=>5}, "Psychology"=>{"Psychology"=>1}, "Nursing and Health Professions"=>{"Nursing and Health Professions"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "reader_count_by_country"=>{"United Kingdom"=>1}, "group_count"=>0}

Scopus | Further Information

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