mRNA N6-methyladenosine methylation of postnatal liver development in pig
Publication Date
March 07, 2017
Authors
Shen He, Hong Wang, Rui Liu, Mengnan He, et al
Volume
12
Issue
3
Pages
e0173421
DOI
https://dx.plos.org/10.1371/journal.pone.0173421
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173421
Scopus
85014761825
Mendeley
http://www.mendeley.com/research/mrna-n6methyladenosine-methylation-postnatal-liver-development-pig
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Mendeley | Further Information

{"title"=>"mRNA N6-methyladenosine methylation of postnatal liver development in pig", "type"=>"journal", "authors"=>[{"first_name"=>"Shen", "last_name"=>"He", "scopus_author_id"=>"56002085100"}, {"first_name"=>"Hong", "last_name"=>"Wang", "scopus_author_id"=>"57188558193"}, {"first_name"=>"Rui", "last_name"=>"Liu", "scopus_author_id"=>"56431636400"}, {"first_name"=>"Mengnan", "last_name"=>"He", "scopus_author_id"=>"56431813400"}, {"first_name"=>"Tiandong", "last_name"=>"Che", "scopus_author_id"=>"56511588800"}, {"first_name"=>"Long", "last_name"=>"Jin", "scopus_author_id"=>"56365070400"}, {"first_name"=>"Lamei", "last_name"=>"Deng", "scopus_author_id"=>"57193546218"}, {"first_name"=>"Shilin", "last_name"=>"Tian", "scopus_author_id"=>"56534547600"}, {"first_name"=>"Yan", "last_name"=>"Li", "scopus_author_id"=>"55918008000"}, {"first_name"=>"Hongfeng", "last_name"=>"Lu", "scopus_author_id"=>"57189378847"}, {"first_name"=>"Xuewei", "last_name"=>"Li", "scopus_author_id"=>"7501709448"}, {"first_name"=>"Zhi", "last_name"=>"Jiang", "scopus_author_id"=>"56346158500"}, {"first_name"=>"Diyan", "last_name"=>"Li", "scopus_author_id"=>"46661131700"}, {"first_name"=>"Mingzhou", "last_name"=>"Li", "scopus_author_id"=>"24081034600"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"pui"=>"614686916", "pmid"=>"28267806", "doi"=>"10.1371/journal.pone.0173421", "issn"=>"19326203", "scopus"=>"2-s2.0-85014761825", "sgr"=>"85014761825", "isbn"=>"1111111111"}, "id"=>"2f78da5e-023b-3171-8598-47f466668415", "abstract"=>"N6-methyladenosine (m6A) is a ubiquitous reversible epigenetic RNA modification that plays an important role in the regulation of post-transcriptional protein coding gene expression. Liver is a vital organ and plays a major role in metabolism with numerous functions. Information concerning the dynamic patterns of mRNA m6A methylation during postnatal development of liver has been long overdue and elucidation of this information will benefit for further deciphering a multitude of functional outcomes of mRNA m6A methylation. Here, we profile transcriptome-wide m6A in porcine liver at three developmental stages: newborn (0 day), suckling (21 days) and adult (2 years). About 33% of transcribed genes were modified by m6A, with 1.33 to 1.42 m6A peaks per modified gene. m6A was distributed predominantly around stop codons. The consensus motif sequence RRm6ACH was observed in 78.90% of m6A peaks. A negative correlation (average Pearson’s r = -0.45, P < 10−16) was found between levels of m6A methylation and gene expression. Functional enrichment analysis of genes consistently modified by m6A methylation at all three stages showed genes relevant to important functions, including regulation of growth and development, regulation of metabolic processes and protein catabolic processes. Genes with higher m6A methylation and lower expression levels at any particular stage were associated with the biological processes required for or unique to that stage. We suggest that differential m6A methylation may be important for the regulation of nutrient metabolism in porcine liver.", "link"=>"http://www.mendeley.com/research/mrna-n6methyladenosine-methylation-postnatal-liver-development-pig", "reader_count"=>16, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>2}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Professor > Associate Professor"=>1, "Student > Doctoral Student"=>2, "Researcher"=>3, "Student > Ph. D. Student"=>2, "Student > Postgraduate"=>2, "Student > Master"=>3, "Student > Bachelor"=>2}, "reader_count_by_subject_area"=>{"Unspecified"=>3, "Biochemistry, Genetics and Molecular Biology"=>5, "Mathematics"=>1, "Medicine and Dentistry"=>2, "Agricultural and Biological Sciences"=>3, "Pharmacology, Toxicology and Pharmaceutical Science"=>1, "Immunology and Microbiology"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>2}, "Immunology and Microbiology"=>{"Immunology and Microbiology"=>1}, "Agricultural and Biological Sciences"=>{"Agricultural and Biological Sciences"=>3}, "Biochemistry, Genetics and Molecular Biology"=>{"Biochemistry, Genetics and Molecular Biology"=>5}, "Mathematics"=>{"Mathematics"=>1}, "Unspecified"=>{"Unspecified"=>3}, "Pharmacology, Toxicology and Pharmaceutical Science"=>{"Pharmacology, Toxicology and Pharmaceutical Science"=>1}}, "group_count"=>1}

Scopus | Further Information

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