A stillbirth calculator: Development and internal validation of a clinical prediction model to quantify stillbirth risk
Publication Date
March 07, 2017
Authors
Amanda S. Trudell, Methodius G. Tuuli, Graham A. Colditz, George A. Macones, et al
Volume
12
Issue
3
Pages
e0173461
DOI
https://dx.plos.org/10.1371/journal.pone.0173461
Publisher URL
http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0173461
Scopus
85014794676
Mendeley
http://www.mendeley.com/research/stillbirth-calculator-development-internal-validation-clinical-prediction-model-quantify-stillbirth
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Mendeley | Further Information

{"title"=>"A stillbirth calculator: Development & internal validation of a clinical prediction model to quantify stillbirth risk", "type"=>"journal", "authors"=>[{"first_name"=>"Amanda S.", "last_name"=>"Trudell", "scopus_author_id"=>"36994071800"}, {"first_name"=>"Methodius G.", "last_name"=>"Tuuli", "scopus_author_id"=>"6505574258"}, {"first_name"=>"Graham A.", "last_name"=>"Colditz", "scopus_author_id"=>"56582809200"}, {"first_name"=>"George A.", "last_name"=>"Macones", "scopus_author_id"=>"7006468240"}, {"first_name"=>"Anthony O.", "last_name"=>"Odibo", "scopus_author_id"=>"7004157930"}], "year"=>2017, "source"=>"PLoS ONE", "identifiers"=>{"isbn"=>"1111111111", "sgr"=>"85014794676", "scopus"=>"2-s2.0-85014794676", "issn"=>"19326203", "pui"=>"614686914", "doi"=>"10.1371/journal.pone.0173461", "pmid"=>"28267756"}, "id"=>"6a1e994c-7bea-3b00-9214-40b1237223fc", "abstract"=>"Objective To generate a clinical prediction tool for stillbirth that combines maternal risk factors to provide an evidence based approach for the identification of women who will benefit most from antenatal testing for stillbirth prevention. Design Retrospective cohort study Setting Midwestern United States quaternary referral center Population Singleton pregnancies undergoing second trimester anatomic survey from 1999+/-2009. Pregnancies with incomplete follow-up were excluded. Methods Candidate predictors were identified from the literature and univariate analysis. Backward stepwise logistic regression with statistical comparison of model discrimination, calibration and clinical performance was used to generate final models for the prediction of stillbirth. Internal validation was performed using bootstrapping with 1,000 repetitions. A stillbirth risk calculator and stillbirth risk score were developed for the prediction of stillbirth at or beyond 32 weeks excluding fetal anomalies and aneuploidy. Statistical and clinical cut-points were identified and the tools compared using the Integrated Discrimination Improvement. Main outcome measures Antepartum stillbirth Results 64,173 women met inclusion criteria. The final stillbirth risk calculator and score included maternal age, black race, nulliparity, body mass index, smoking, chronic hypertension and pre-gestational diabetes. The stillbirth calculator and simple risk score demonstrated modest discrimination but clinically significant performance with no difference in overall performance between the tools [(AUC 0.66 95% CI 0.60+/-0.72) and (AUC 0.64 95% CI 0.58+/-0.70), (p = 0.25)]. Conclusion A stillbirth risk score was developed incorporating maternal risk factors easily ascertained during prenatal care to determine an individual woman's risk for stillbirth and provide an evidenced based approach to the initiation of antenatal testing for the prediction and prevention of stillbirth.Copyright © 2017 Trudell et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.", "link"=>"http://www.mendeley.com/research/stillbirth-calculator-development-internal-validation-clinical-prediction-model-quantify-stillbirth", "reader_count"=>2, "reader_count_by_academic_status"=>{"Unspecified"=>1, "Student > Master"=>1}, "reader_count_by_user_role"=>{"Unspecified"=>1, "Student > Master"=>1}, "reader_count_by_subject_area"=>{"Unspecified"=>1, "Medicine and Dentistry"=>1}, "reader_count_by_subdiscipline"=>{"Medicine and Dentistry"=>{"Medicine and Dentistry"=>1}, "Unspecified"=>{"Unspecified"=>1}}, "group_count"=>0}

Scopus | Further Information

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